WADA Takayuki

写真a

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Title

Professor

Laboratory location

Sugimoto Campus

Research Areas 【 display / non-display

molecular epidemiology of infectious diseases, Genome microbiology

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Human Life Science   Human Life Science Course   Professor  

Graduate School 【 display / non-display

  • 1997.04
    -
    1999.03

    Kyoto University  Graduate School, Division of Natural Science 

Graduating School 【 display / non-display

  • 1993.04
    -
    1997.03

    Kyoto University   Faculty of Science  

 

Published Papers 【 display / non-display

  • Seroepidemiological survey on pigs and cattle for novel K88 (F4)-like colonization factor detected in human enterotoxigenic Escherichia coli

    Yoshihiko Tanimoto, Miyoko Inoue, Kana Komatsu, Atsuyuki Odani, Takayuki Wada, Eriko Kage-Nakadai, Yoshikazu Nishikawa

    Epidemiology and Infection  2021  [Refereed]

     View Summary

    Enterotoxigenic Escherichia coli (ETEC) strains that express various fimbrial or nonfimbrial colonization factors and enterotoxins are critical causes of diarrheal diseases. Human ETEC serotype O169:H41 (O169) has been a representative of epidemic ETEC worldwide; the organism shows massive adherence to HEp-2 cells similar to enteroaggregative E. coli. Previously, we determined the complete sequence of the unstable virulence plasmid, pEntYN10. The plasmid included a unique set of genes encoding a novel colonization factor (CF) resembling K88 (F4) of porcine ETEC, in addition to CS6, a well-known representative CF of human ETEC, and another novel CF similar to CS8 (CFA/III) of human ETEC. In the present study, we focused on K88-like CF (hereafter, K88O169) that may allow the organisms to infect domestic livestock like original K88-harboring strains that can cause diarrhea in piglets. Samples were tested for antibodies against recombinant proteins of possible paralogous adhesins, FaeG1 and FaeG2, from K88O169 and the FaeG of typical K88 (F4). The seroepidemiological study using recombinant antigens (two paralogs FaeG1 and FaeG2 from K88Oi69) showed reactivity of porcine (18.0%) and bovine (17.1%) sera to K88O169 FaeG1 and/or FaeG2 antigens on indirect ELISA tests. These results suggest that E. coli with K88O169 adhesin can infect various hosts, including pigs and cattle. This is the first report of domestic livestock having antibodies to K88O169 of human ETEC. Although human ETEC had been thought to be distinguished from those of domestic animals based on colonization factors, zoonotic strains may conceal themselves among human ETEC organisms. The concept of One Health should be adopted to intervene in ETEC infections among animals and humans.

    DOI

  • Deep sequence analysis of NS5A resistance-associated substitution changes in patients reinfected with the hepatitis C virus after liver transplantation.

    Yamamichi S, Miuma S, Wada T, Masumoto H, Kanda Y, Shibata H, Miyaaki H, Taura N, Ichikawa T, Yamamoto T, Nakao K

    Journal of viral hepatitis  2020.01  [Refereed]

    DOI PubMed

  • Pseudo-outbreak of Mycobacterium chimaera through aerators of hand-washing machines at a hematopoietic stem cell transplantation center.

    Nakamura S, Azuma M, Sato M, Fujiwara N, Nishino S, Wada T, Yoshida S

    Infection Control & Hospital Epidemiology  40 ( 12 ) 1433 - 1435 2019.12  [Refereed]

    DOI

  • Distribution of Carnivore protoparvovirus 1 in free-living leopard cats (Prionailurus bengalensis chinensis) and its association with domestic carnivores in Taiwan

    Chen CC, Chang AM, Wada T, Chen MT, Tu YS

    PLoS ONE  14 ( 9 ) e0221990 2019.09  [Refereed]

    DOI

  • Draft genome sequence of Vibrio harveyi strain GAN1807 isolated from diseased greater amberjack (Seriola dumerili) farmed in Japan in 2018.

    Kato Y, Wada T, Yamashita H, Ikeda T, Nishiyama K, Imajoh M

    Microbiology Resource Announcements  8 ( 34 ) e00629-19 2019.08

    DOI

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Books etc 【 display / non-display

  • BCG –Vaccine and Adjuvant–

    Wada T, Iwamoto T (Part: Single Work )

    JATA Press  2011

Grant-in-Aid for Scientific Research 【 display / non-display

  • Uncovering transmission of tuberculosis based on spatial molecular epidemiology with person flow data

    Project/Area Number : 20H03932  Grant-in-Aid for Scientific Research(B) Representative

    Project Year :

    2020.04
    -
    2023.03
     

  • Host adaptation and niche expansion of pathogenic bacteria: a new approach of microbial ecology based on molecular evolution of colonization factors

    Project/Area Number : 19K22459  Grant-in-Aid for Challenging Research (Exploratory) Representative

    Project Year :

    2019.06
    -
    2021.03
     

  • The impacts of artificial disturbances on wildlife ecology and physiology

    Project/Area Number : 18H02218  Grant-in-Aid for Scientific Research(B) Partaker / Other

    Project Year :

    2018.04
    -
    2022.03
     

  • Tracing of transmission routes of tuberculosis using geographical information of patients and genetic analysis of clinical isolates

    Project/Area Number : 17H04136  Grant-in-Aid for Scientific Research(B) Representative

    Project Year :

    2017.04
    -
    2020.03
     

  • Surveillance of pathogenic mycobacteria in Asian and Oceanian countries

    Project/Area Number : 15H05263  Grant-in-Aid for Scientific Research(B) Representative

    Project Year :

    2015.04
    -
    2019.03
     

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