SHINADA Tetsuro

写真a

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Title

Professor

Laboratory location

Sugimoto Campus

Degree 【 display / non-display

  • Kobe Pharmaceutical University -  Doctor of Pharmaceutical Science

Research Areas 【 display / non-display

natural products chemistry, Total synthesis

Research Career 【 display / non-display

  • Chemical Biology of Natural Products

    (Collaboration in Japan) Project Year :

    1996.04
    -
    Today

    Keyword in research subject:  Natural products

  • Development of New Synthetic Methology

    (Collaboration in Japan) Project Year :

    1996.04
    -
    Today

Association Memberships 【 display / non-display

  • THE CHEMICAL SOCIETY OF JAPAN

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Science   Molecular Materials Science Course   Professor  

Graduate School 【 display / non-display

  •  
    -
    1992

    Kobe Pharmaceutical University  Graduate School, Division of Pharmaceutical Sciences 

Graduating School 【 display / non-display

  •  
    -
    1987

    Setsunan University   Faculty of Pharmaceutical Science  

 

Published Papers 【 display / non-display

  • Reconstitution of a Highly Reducing Type II PKS System Reveals 6π-Electrocyclization Is Required for <i>o</i>-Dialkylbenzene Biosynthesis.

    Zhang J, Yuzawa S, Thong WL, Shinada T, Nishiyama M, Kuzuyama T

    Journal of the American Chemical Society  143 ( 7 ) 2962 - 2969 2021.02  [Refereed]

    DOI PubMed

  • Stereoselective Synthesis of (2S,6R)-Diamino-(5R,7)-dihydroxy-heptanoic Acid (DADH): An Unusual Amino Acid from Streptomyces sp. SANK 60404

    Okamura Hironori, Yasuno Yoko, Nakayama Atsushi, Takikawa Hirosato, Shinada Tetsuro

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY  2021.02  [Refereed]

    DOI

  • A novel cyclic peptide (Naturido) modulates glia-neuron interactions in vitro and reverses ageing-related deficits in senescence-accelerated mice.

    Ishiguro S, Shinada T, Wu Z, Karimazawa M, Uchidate M, Nishimura E, Yasuno Y, Ebata M, Sillapakong P, Ishiguro H, Ebata N, Ni J, Jiang M, Goryo M, Otsu K, Harada H, Suzuki K

    PloS one  16 ( 1 ) e0245235 2021  [Refereed]

    DOI PubMed

  • Ovicidal activity of juvenile hormone mimics in the bean bug, <i>Riptortus pedestris</i>

    Naruse Shouya, Ogino Mayuko, Nakagawa Takao, Yasuno Yoko, Jouraku Akiya, Shiotsuki Takahiro, Shinada Tetsuro, Miura Ken, Minakuchi Chieka

    日本農薬学会 日本農薬学会誌(Journal of Pesticide Science)  2021  [Refereed]

     View Summary

    <p>Insect juvenile hormone (JH) mimics (JHMs) are known to have ovicidal effects if applied to adult females or eggs. Here, we examined the effects of exogenous JHMs on embryonic development of the bean bug, <i>Riptortus pedestris</i>. The expression profiles of JH early response genes and JH biosynthetic enzymes indicated that JH titer was low for the first 3 days of the egg stage and increased thereafter. Application of JH III skipped bisepoxide (JHSB<sub>3</sub>) or JHM on Day 0 eggs when JH titer was low caused reduced hatchability, and the embryos mainly arrested in mid- or late embryonic stage. Application of JHMs on Day 5 eggs also resulted in an arrest, but this was less effective compared with Day 0 treatment. Interestingly, ovicidal activity of synthetic JHMs was much lower than that of JHSB<sub>3</sub>. This study will contribute to developing novel insecticides that are selective among insect species.</p>

    DOI CiNii

  • Diverse Aromatic Metabolites in the Solitary Tunicate Cnemidocarpa irene

    Miyako Kei, Yasuno Yoko, Shinada Tetsuro, Fujita Masaki J., Sakai Ryuichi

    JOURNAL OF NATURAL PRODUCTS  83 ( 10 ) 3156 - 3165 2020.10  [Refereed]

     View Summary

    © 2020 American Chemical Society. All rights reserved. Fourteen aromatic metabolites (6-19) were isolated from an aqueous extract of the solitary tunicate Cnemidocarpa irene collected in Hokkaido, Japan. The structures of the metabolites were determined based on the spectroscopic interpretations, including one- and two-dimensional NMR, mass spectra, UV, and circular dichroism data. The biopterin analogue 10 modulated the behavior of mice after intracerebroventricular injection and showed a weak affinity to ionotropic glutamate receptor subtypes. Analyses of fluorescent coelomic fluid of the tunicate revealed that pterin 12 was responsible for the fluorescence of the blood cells, while β-carbolines 1 and 3 were fluorescent compounds in the serum. The metabolic profiles in adults, juveniles, larvae, and eggs of the animal differed substantially, suggesting that the metabolism of the animal, especially biosynthesis of aromatic secondary metabolites, changes over different life stages.

    DOI PubMed

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Books etc 【 display / non-display

  • Neuroprotective Properties of the Fungus Isaria Japonica: Evidence from a Mouse Model of Aged Related Degeneration

    K. Suzuki, M. Tsushima1, M. Goryo, T. Shinada, Y. Yasuno, E. Nishimura, Y.Terayama, Y. Mori, Y. Yoshioka (Part: Joint Work )

    Frontiers in Clinical Drug Research-Alzheimer Disorder; Vol. 2, Bentham e-Books series  2017.04

Review Papers (Misc) 【 display / non-display

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Conference Activities & Talks 【 display / non-display

  • Synthetic Study of Phomopsin A : Catalytic Asymmetric Synthesis of β-OH-DOPA

    Kohei Yasuda, Yoko Yasuno, Tetsuro Shinada

    27th International Sciety of Heterocyclic Chemistry Congress  2019.09 

  • First Total Synthesis of Antrimycin A and D

    Yoko Yasuno, Akito Nishimura, Akira Sawai, Ai Sekihara, Tetsuro Shinada

    27th International Sciety of Heterocyclic Chemistry Congress  2019.09 

  • Synthesis of Polyfunctional Carotenoid by Cross-Coupling Strategy

    K. Sakaguchi, Y. Nishioka, N. Kinashi, T. Shinada, T. Nishimura, H. Hashimoto, S. Katsumura

    The 20th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS 20)  2019.06 

  • Stereochemistry of the β-Arginine Unit of SF-2132

    Ai Sekihara, Yoko Yasuno, Tetsuro Shinada

    日本化学会 第99回春季年会(2019)  (兵庫県神戸市、甲南大学岡本キャンパス)  2019.03  日本化学会

  • Synthetic Study of Ustiloxin D by Using Isonitrile Aldol Reaction

    Kazuma Fuku, Yoko Yasuno, Tetsuro Shinada

    日本化学会 第99回春季年会(2019)  (兵庫県神戸市、甲南大学岡本キャンパス)  2019.03  日本化学会

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Grant-in-Aid for Scientific Research 【 display / non-display

  • Identification of new target molecule using natural products: Toward development of anti tuberculosis molecules

    Project/Area Number : 20H02869  Grant-in-Aid for Scientific Research(B) Representative

    Project Year :

    2020.04
    -
    2024.03
     

  • Functional analysis of terpene synthases and its application to the synthesis of unusual terpenoids

    Project/Area Number : 19H04661  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area) Representative

    Project Year :

    2019.04
    -
    2021.03
     

  • Synthetic study of chiral compounds by taking advantage of an umpolung approach

    Project/Area Number : 17K08216  Grant-in-Aid for Scientific Research(C) Representative

    Project Year :

    2017.04
    -
    2021.03
     

  • Synthetic Study of Acyclic Terpene Probes to Elucidate the Reaction Mechanism of Terpenoid Biosynthesis

    Project/Area Number : 17H05448  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area) Representative

    Project Year :

    2017.04
    -
    2019.03
     

  • Exploitation of niches and diversification of organisms by utilising invisible light: the new research field of photogeobiology

    Project/Area Number : 16K13898  Grant-in-Aid for challenging Exploratory Research Representative

    Project Year :

    2016.04
    -
    2018.03
     

    Partaker : ADACHI Natsuko, TOKUDA Yuki, SENTOKU Asuka

     View Summary

    Marine algae include many kinds of UV-absorbing compounds (mycosporine-like amino acids, MAAs), which occur in various proportions. Zooxanthellate dendrophylliid corals also contain MAAs, although with less variability in the proportions of different compounds than algae. In contrast, azooxanthellate dendrophylliids contain various types of photo-absorbing compounds that differ from MAAs. In addition, the zooxanthellate coral Oulastrea crispata possibly biosynthesises MAAs, and its black pigment in skeletons is derived from protoporphyrin. The organisms examined in this research take effective measures against UV irradiation, and instead of photosynthesis. They biosynthesise photo-related compounds in photoenvironments unique to the habitat conditions. The inclusion of protoporphyrin in skeletons indicates a defence mechanism against microbial impact in habitat niches. The results provide clues to the biochemical responses of organisms that aid in the exploitation of special niches.

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Foreigner acceptance 【 display / non-display

  • Academic year : 2020

     View Details

    Number of foreigners accepted
    0
    Number of International Students
    0