SHINADA Tetsuro

写真a

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Title

Professor

Laboratory location

Sugimoto Campus

Degree 【 display / non-display

  • Kobe Pharmaceutical University -  Doctor of Pharmaceutical Science

Research Areas 【 display / non-display

natural products chemistry, Total synthesis

Research Career 【 display / non-display

  • Chemical Biology of Natural Products

    (Collaboration in Japan) Project Year :

    1996.04
    -
    Today

    Keyword in research subject:  Natural products

  • Development of New Synthetic Methology

    (Collaboration in Japan) Project Year :

    1996.04
    -
    Today

Association Memberships 【 display / non-display

  • THE CHEMICAL SOCIETY OF JAPAN

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Science   Molecular Materials Science Course   Professor  

Graduate School 【 display / non-display

  •  
    -
    1992

    Kobe Pharmaceutical University  Graduate School, Division of Pharmaceutical Sciences 

Graduating School 【 display / non-display

  •  
    -
    1987

    Setsunan University   Faculty of Pharmaceutical Science  

 

Published Papers 【 display / non-display

  • Catalytic Asymmetric Hydrogenation of Dehydroamino Acid Ester with Biscarbamate Protection and Its Application to Synthesis of xCT inhibitor.

    Yasuno Y, Mizutani I, Sueuchi Y, Wakabayashi Y, Yasuo N, Shimamoto K, Shinada T

    Chemistry (Weinheim an der Bergstrasse, Germany)  2019.02  [Refereed]

    DOI PubMed

  • Chiral isoxazolidine-mediated stereoselective umpolung alpha-phenylation of methyl ketones

    Takeda Norihiko, Furuishi Mizuki, Nishijima Yuri, Futaki Erika, Ueda Masafumi, Shinada Tetsuro, Miyata Okiko

    ORGANIC & BIOMOLECULAR CHEMISTRY  16 ( 46 ) 8940 - 8943 2018.12  [Refereed]

    DOI PubMed

  • An Aromatic Farnesyltransferase Functions in Biosynthesis of the Anti-HIV Meroterpenoid Daurichromenic Acid

    Saeki Haruna, Hara Ryota, Takahashi Hironobu, Iijima Miu, Munakata Ryosuke, Kenmoku Hiromichi, Fuku Kazuma, Sekihara Ai, Yasuno Yoko, Shinada Tetsuro, Ueda Daijiro, Nishi Tomoyuki, Sato Tsutomu, Asakawa Yoshinori, Kurosaki Fumiya, Yazaki Kazufumi, Taura Futoshi

    PLANT PHYSIOLOGY  178 ( 2 ) 535 - 551 2018.10  [Refereed]

    DOI PubMed

  • Improved total synthesis of (+/-)-Tetragocarbone A

    Nishimura Eiji, Yasuno Yoko, Shinada Tetsuro

    TETRAHEDRON  74 ( 21 ) 2664 - 2668 2018.05  [Refereed]

    DOI

  • Crystal structure and functional analysis of large-terpene synthases belonging to a newly found subclass

    Fujihashi Masahiro, Sato Tsutomu, Tanaka Yuma, Yamamoto Daisuke, Nishi Tomoyuki, Ueda Daijiro, Murakami Mizuki, Yasuno Yoko, Sekihara Ai, Fuku Kazuma, Shinada Tetsuro, Miki Kunio

    CHEMICAL SCIENCE  9 ( 15 ) 3754 - 3758 2018.04  [Refereed]

    DOI

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Books etc 【 display / non-display

  • Neuroprotective Properties of the Fungus Isaria Japonica: Evidence from a Mouse Model of Aged Related Degeneration

    K. Suzuki, M. Tsushima1, M. Goryo, T. Shinada, Y. Yasuno, E. Nishimura, Y.Terayama, Y. Mori, Y. Yoshioka (Part: Joint Work )

    Frontiers in Clinical Drug Research-Alzheimer Disorder; Vol. 2, Bentham e-Books series  2017.04

Review Papers (Misc) 【 display / non-display

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Conference Activities & Talks 【 display / non-display

  • Synthetic Study of Ustiloxin D by Using Isonitrile Aldol Reaction

    Kazuma Fuku, Yoko Yasuno, Tetsuro Shinada

    日本化学会 第99回春季年会(2019)  (兵庫県神戸市、甲南大学岡本キャンパス)  2019.03  日本化学会

  • Stereochemistry of the β-Arginine Unit of SF-2132

    Ai Sekihara, Yoko Yasuno, Tetsuro Shinada

    日本化学会 第99回春季年会(2019)  (兵庫県神戸市、甲南大学岡本キャンパス)  2019.03  日本化学会

  • Synthetic Study of Phomopsin A: Catalytic Asymmetric Synthesis of the Amino Acid Unit

    Kohei Yasuda, Yoko Yasuno, Tetsuro Shinada

    日本化学会 第99回春季年会(2019)  (兵庫県神戸市、甲南大学岡本キャンパス)  2019.03  日本化学会

  • Catalytic Asymmetric Synthesis of Orthogonally Protected N-Acyl 2,7-Diaminosuberic Acid

    Yoko Yasuno, Iho Mizutani, Yuki Sueuchi, Yuuka Wakabayashi, Nozomi Yasuo, Keiko Shimamoto, Tetsuro Shinada

    The 13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13)   (Rihga Royal Hotel, KYOTO, JAPAN,)  2018.11  IKCOC-13

  • Polyfunctional Carotenoid Synthesis via Cross-Coupling Strategy

    Kazuhiko Sakaguchi, Yuto Nishioka, Naoto Kinashi, Tetsuro Shinada, Takahiro Nishimura, Hideki Hashimoto, Shigeo Katsumura

    The 13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13)  (Rihga Royal Hotel, KYOTO, JAPAN)  2018.11  IKCOC-13

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Grant-in-Aid for Scientific Research 【 display / non-display

  • Synthetic study of chiral compounds by taking advantage of an umpolung approach

    Project/Area Number : 17K08216  Grant-in-Aid for Scientific Research(C) Partaker / Other

    Project Year :

    2017.04
    -
    2021.03
     

  • Synthetic Study of Acyclic Terpene Probes to Elucidate the Reaction Mechanism of Terpenoid Biosynthesis

    Project/Area Number : 17H05448  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area) Representative

    Project Year :

    2017.04
    -
    2019.03
     

  • Exploitation of niches and diversification of organisms by utilising invisible light: the new research field of photogeobiology

    Project/Area Number : 16K13898  Grant-in-Aid for challenging Exploratory Research Partaker / Other

    Project Year :

    2016.04
    -
    2018.03
     

  • Development of new anchor molecule to fix biologically active molecules on cell surface

    Project/Area Number : 15K12758  Grant-in-Aid for challenging Exploratory Research Representative

    Project Year :

    2015.04
    -
    2018.03
     

  • Development of novel synthetic reactions based on mutual cooperation of nitrogen-oxygen bonds and multiple bonds

    Project/Area Number : 26460024  Grant-in-Aid for Scientific Research(C) Partaker / Other

    Project Year :

    2014.04
    -
    2017.03
     

    Partaker : UEDA Masafumi, MIYOSHI Tetsuya

     View Summary

    Aiming to the development of useful methods for the synthesis of biologically active compounds, we have developed new synthetic reactions in which functional groups and multiple bonds mutually cooperate. Alkoxyamines, alkoxyamides, and oxime ethers having nitrogen and oxygen bonds were selected as substrates in this study. As a result, various new carbon-carbon forming reactions featured by the polarity inversion of carbonyl functionality and unprecedented cascade reactions were developed. Treatment of N-alkoxyenamines with triarylaluminum reagents afforded alfa-arylcarbonyls. Alkoxyamides with an alkenyl or alkynyl group underwent cyclization-rearrangement reaction to give isoxazole derivatives. Oxime ethers enabled to be converted to substituted benzofuropyrroles by triethylborane-mediated radical addition-rearrangement-cyclization-lactamization. Under the same conditions, hydrazones were transformed to indoleacetic acid derivatives.

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