Tsuruta Daisuke

写真a

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Title

Professor

Laboratory location

Abeno Campus

Profile

MEDICAL SCHOOL: Osaka City University Medical School, 1986-92, M.D., Medicine GRADUATE SCHOOL: Osaka City University Graduate School of Medicine, 1994-1999, Ph.D. Thesis: In vivo activation of Langerhans cells and dendritic epidermal T cells in the elicitation phase of murine contact hypersensitivity.
RESIDENCY: Osaka City University Hospital, Dermatology, 1992-1994
FELLOWSHIP: Nagasaki University Medical School, Department of Cell Biology and Histology with Dr. Takehiko Koji, 1998-99: In situ hybridization/Apoptosis/Renal biology
Northwestern University the Feinberg School of Medicine,
Department of Cell and Molecular Biology with Dr. Jonathan CR Jones, 2000-2003: Cutaneous basement
membrane studies/Immunogold for endothelial cells/live
cell imaging for the matrix adhesion
(hemidesmosomes/focal contacts)
HONORS: Osaka City Mayor's Award 1999
United States Army Breast Cancer Fellowship 2000
Gramm Travel Fellowship 2001
Albert M Kligman Fellowship 2001
Travel Award by American Academy of Dermatology 2003
Japanese Association for Contact Dermatitis Art Award
2003
Western Branch of the Japanese Association for
Dermatologists President's Award 2004
Osaka City Mayor's Award 2008
Shiseido Basic Research Grant 2011
Society for Cutaneous Ultrastructural Research Best Oral
Award 2013
Society for Medical Molecular Morphology Best Oral
Award 2019
CERTIFICATION: Japanese Board of Dermatology (September, 1998)
ACADEMIC POSITION: Clinical Assistant Professor, Dermatology, Osaka City University Hospital, Osaka Japan, 2003-2005
Assistant Professor, Dermatology
Osaka City University Graduate School of Medicine,
2005-2010
Associate Professor, Dermatology
Kurume University Medical School and Kurume Institute of Cutaneous Cell Biology, 2011
Assistant Professor, Dermatology
Osaka City University Graduate School of Medicine,
2011-2012 Visiting Associate Professor, Dermatology, Kurume University School of Medicine, 2011-2013
Professor and Chairman, Osaka City University Graduate School of Medicine,
2013-present, Invited Professor, Dermatology, Kurume University School Medicine, 2013-present
Assistant to the Director, Osaka City University Hospital,
2015-2017
Assistant to the Dean, Osaka City University Graduate
School of Medicine, 2017-2019
Specially appointed Vice President, Osaka City
University, 2019-present
Director of International Office, Osaka City University,
2019-present

Degree 【 display / non-display

  • Osaka City University -  MD, PhD

Research Areas 【 display / non-display

Autoimmune bullous dermatosis, psoriasis, wound healing

Research subject summary 【 display / non-display

  • Elucidation of the pathomechanism of bullous pemphigoid
    Hair regeneration
    Enhancing skin wound healing
    Photodynamic therapy on skin infection.

Research Interests 【 display / non-display

Autoimmune bullous disease, Psoriasis, Infectious control, hemidesmosome

Research Career 【 display / non-display

  • immunology in the epidermis

    (Collaboration in Organization) Project Year :

    1994.04
    -
    1999.03

    Keyword in research subject:  Interaction between Langerhans cells and dendritic epidermal T cells

  • Dynamics of the hemidesmosome

    (International Collaboration) Project Year :

    2000.04
    -
    Today

  • Dynamics of focal contact (adhesion)

    (International Collaboration) Project Year :

    2000.04
    -
    Today

  • Interaction between hemidesmosome and focal adhesion

    (International Collaboration) Project Year :

    2003.04
    -
    Today

  • Pathomechanism of bullous pemphigoid

    (International Collaboration) Project Year :

    2010.04
    -
    Today

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Education summary 【 display / non-display

  • Basic skin morphology
    Dermatology basics
    Vascular diseases and drug reaction
    eczema and dermatitis

Association Memberships 【 display / non-display

  • Japanese Psoriasis association

  • Japanese society for skin pathology

  • Association of bullous diseases

  • Japanese association of psychology and dermatology

  • Society for Investigative Dermatology

Committee Memberships 【 display / non-display

  • 2017.04
    -
    Today

    Japanese society for allergy   delegate

Awards & Honors 【 display / non-display

  • Japanese associattion of clinical morpholgy award

    2013  

  • Poster award in contact dermatitis

    2004  

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Medicine   Clinical Medicine Course   Professor  

  • Osaka City University   President / Vice President etc   Global Exchange Office   Specially Appointed Vice President  

  • Osaka City University   Director in General  

Career 【 display / non-display

  • 2011.04
    -
    2011.09

    Osaka City University   Medical School   Assistant Professor

Graduate School 【 display / non-display

  •  
     
     

    Osaka City University  Graduate School, Division of Medical Sciences 

Graduating School 【 display / non-display

  •  
    -
    1992

    Osaka City University   Faculty of Medicine  

 

Published Papers 【 display / non-display

  • Local Epidermal Endocrine Estrogen Protects Human Melanocytes against Oxidative Stress, a Novel Insight into Vitiligo Pathology.

    Yamamoto A, Yang L, Kuroda Y, Guo J, Teng L, Tsuruta D, Katayama I

    International journal of molecular sciences  22 ( 1 )  2020.12  [Refereed]

    DOI PubMed

  • A Case of Dapsone-induced Mild Methemoglobinemia with Dyspnea and Cyanosis.

    Hayama Y, Imanishi H, Yoshimoto N, Sugawara K, Tsuruta D

    Acta dermatovenerologica Croatica : ADC  28 ( 4 ) 249 - 250 2020.12  [Refereed]

    PubMed

  • Successful long-term treatment with pazopanib after prior interleukin-2 therapy in patients with metastatic cutaneous angiosarcoma of the scalp.

    Watanabe M, Nakai K, Iwaki Y, Ozawa T, Kamo R, Tsuruta D

    Dermatologic therapy  33 ( 6 ) e14007 2020.11  [Refereed]

    DOI PubMed

  • Bacteremic cellulitis mimicking erythema nodosum caused by Streptococcus sanguinis endocarditis.

    Nishida M, Imanishi H, Sowa-Osako J, Umeda S, Ito A, Yasumizu D, Yoshiyama M, Tsuruta D

    International journal of dermatology  59 ( 11 ) e425 - e427 2020.11  [Refereed]

    DOI PubMed

  • 血清TARC値が病勢評価に有用であった尋常性乾癬に合併した抗ラミニンγ1類天疱瘡の1例

    川島 秀介, 宮地 秀明, 松岡 悠美, 立石 千晴, 鶴田 大輔, 松江 弘之

    (株)医学書院 臨床皮膚科  74 ( 11 ) 871 - 876 2020.10  [Refereed]

     View Summary

    <文献概要>63歳,男性.53歳時から尋常性乾癬あり.初診1ヵ月前より下肢を中心に緊満性水疱が多発するようになり当科を受診した.血清抗BP180抗体,抗デスモグレイン1および3抗体は陰性,血清TARC値は高値であった.病理組織学的に表皮下水疱を認め,蛍光抗体直接法で表皮真皮境界部にC3とIgGの線状沈着があり,蛍光抗体間接法でIgG抗表皮基底膜部抗体を認めた.1M食塩水剥離ヒト皮膚を基質とした蛍光抗体間接法では真皮側にIgGの線状沈着があり,正常ヒト真皮抽出液を用いた免疫ブロット法にて,患者血清中のIgGは200kDa蛋白質に陽性であった.以上から,抗ラミニンγ1類天疱瘡と診断した.治療はステロイド全身投与とメトトレキサートで行い,現在メトトレキサート単剤で抗ラミニンγ1類天疱瘡と尋常性乾癬の両疾患を寛解維持している.経過中の皮膚症状の増悪と血清TARC値の増減が一致しており,病勢との相関が示唆された.

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Books etc 【 display / non-display

Review Papers (Misc) 【 display / non-display

  • Autophagy-related protein expression in granulomatous skin diseases(和訳中)

    Yanagihara Shigeto, Okazaki Hidenori, Sugawara Koji, Ozawa Toshiyuki, Sayama Koji, Yamamoto Osamu, Tsuruta Daisuke, Nakai Kozo

    John Wiley & Sons Australia, Ltd The Journal of Dermatology  47 ( 10 ) e364 - e366 2020.10  [Refereed]  [Invited]

  • Your Diagnosis! 多中心性細網組織球症(MRH)

    鶴田 大輔

    (株)学研メディカル秀潤社 Visual Dermatology  19 ( 10 ) 1064 - 1065 2020.09  [Refereed]  [Invited]

  • 【皮膚疾患をもつ高齢者を診る】類天疱瘡と天疱瘡 高齢者に多い自己免疫性水疱症

    林 大輔, 鶴田 大輔

    (株)ライフ・サイエンス Geriatric Medicine  58 ( 8 ) 703 - 709 2020.08  [Refereed]  [Invited]

     View Summary

    中高年に多い自己免疫性水疱症として、尋常性天疱瘡と落葉状天疱瘡、高齢者に多い水疱症として、水疱性類天疱瘡が存在する。尋常性天疱瘡は口腔粘膜に疼痛を伴う難治性びらんを認め、皮膚には弛緩性水疱、びらんを生じる。落葉状天疱瘡は脂漏部位、躯幹に薄い鱗屑、痂皮を有する紅斑と小型の浅い水疱を形成する。水疱性類天疱瘡は全身の皮膚に浮腫性紅斑や緊満性水疱を呈し、粘膜病変を認める場合もある。これらは標的抗原も異なり、尋常性天疱瘡はデスモグレイン1、3(Dsg1、3)、落葉状天疱瘡はDsg1、水疱性類天疱瘡はBP180を主な標的抗原としている。いずれもステロイド全身投与が主な治療法である。また近年、糖尿病の治療薬であるDipeptidyl Peptidase-4(DPP-4)阻害薬と関連する水疱性類天疱瘡が報告され、注目を集めている。(著者抄録)

  • 水疱性類天疱瘡における自己抗原内在化の機序

    廣保 翔, Granville David J., 鶴田 大輔

    (株)北隆館 アレルギーの臨床  40 ( 7 ) 583 - 586 2020.07  [Refereed]  [Invited]

     View Summary

    水疱性類天疱瘡は、そう痒を伴う全身の緊満性水疱を特徴とする自己免疫性水疱症である。標準治療は内服または外用ステロイドであるが、罹患患者の大半を占める高齢者における免疫抑制等の副作用や、標準治療に反応しづらい難治例が臨床上しばしば問題となる。このために、水疱性類天疱瘡の詳細な発症機序の理解と、それに基づいた新規治療法が求められている。これまでに水疱性類天疱瘡の発症には、表皮真皮間接着因子である17型コラーゲンに対する自己抗体が、補体やプロテアーゼを活性化することが重要であると考えられてきた。しかし近年、われわれを含む複数のグループが、自己抗体は17型コラーゲンを内在化させ表皮細胞の接着力を減弱させていることを明らかにした。本稿では、近年明らかになった水疱性類天疱瘡における自己抗原内在化の機序をまとめ、その疾患における意義を考察する。(著者抄録)

  • 【最近のトピックス2020 Clinical Dermatology 2020】皮膚科医のための臨床トピックス 光線力学療法(PDT)による感染皮膚潰瘍治療

    小澤 俊幸, 粟津 邦男, 鶴田 大輔

    (株)医学書院 臨床皮膚科  74 ( 5 ) 181 - 183 2020.04  [Refereed]  [Invited]

     View Summary

    <文献概要>われわれは,5-aminolevulinic acid(ALA)を用いた光線力学療法(PDT)で,MRSAおよび緑膿菌感染マウス皮膚潰瘍を治療し,殺菌および創傷治癒促進作用があることを報告した.今回,倫理委員会の承認のもと,ヒトのMRSA感染皮膚潰瘍に対してALA-PDTを行ったところ,明らかな有害事象を認めず速やかな上皮化により,治癒させることができたので報告する.

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Conference Activities & Talks 【 display / non-display

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Charge of on-campus class subject 【 display / non-display

  • Dermatology CC

    (2019) University, General education courses

  • Dermatology CC

    (2018) University, General education courses

  • Dermatology CC

    (2017) University, General education courses

Other educational activity and Special note 【 display / non-display

  • Improvement of educational methods

    (2018)

Educational activity record 【 display / non-display

  • Academic year : 2019

     View Details

    Number of instructed the graduation thesis
    0
    Number of graduation thesis reviews
    0
    Number of instructed the Doctoral course
    12
    Number of master's thesis reviews (chief)
    1
    Number of doctoral thesis reviews (vice-chief)
    1
  • Academic year : 2018

     View Details

    Number of instructed the graduation thesis
    0
    Number of graduation thesis reviews
    0
    Number of instructed the Doctoral course
    11
    Number of master's thesis reviews (chief)
    0
    Number of master's thesis reviews (vice-chief)
    0
    Number of doctoral thesis reviews (chief)
    3
    Number of doctoral thesis reviews (vice-chief)
    3
  • Academic year : 2017

     View Details

    Number of instructed the graduation thesis
    0
    Number of graduation thesis reviews
    0
    Number of instructed the Master course
    0
    Number of instructed the Doctoral course
    9
    Number of master's thesis reviews (chief)
    0
    Number of master's thesis reviews (vice-chief)
    0
    Number of doctoral thesis reviews (chief)
    2
    Number of doctoral thesis reviews (vice-chief)
    0
 

Theme of Possible Research Exchange 【 display / non-display

  • Photodynamic therapy for skin infection

    Research theme : Infectious ulcer in the skin is treated by photodynamic therapy

    Type of research exchange : Consignment study, Collaborative research, Lecture

 

Foreigner acceptance 【 display / non-display

  • Academic year : 2017

     View Details

    Number of foreigners accepted
    2
    Number of International Students
    15

    Egypt

Other international activities 【 display / non-display

  • Period :

    2017.09
    -
    Today

    Contents of activities : Vietnamese Society for Dermatology

    Vietnam

  • Period :

    2017.09
    -
    Today

    Contents of activities : Asian Academy of Dermatology and Venereology

    Vietnam