KAGE-NAKADAI Eriko

写真a

Search Institutional Repository


Title

Professor

Laboratory location

Sugimoto Campus

Alternative names

Eriko KAGE

Research Areas 【 display / non-display

Eating habits, Bacteriology (including mycology), General physiology

Association Memberships 【 display / non-display

  • American Society for Microbiology

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Human Life Science   Human Life Science Course   Professor  

Graduate School 【 display / non-display

  • 2001.04
    -
    2004.03

    The University of Tokyo  Graduate School, Division of Pharmaceutical Sciences 

  • 1999.04
    -
    2001.03

    Kyushu University  Graduate School, Division of Pharmaceutical Sciences 

Graduating School 【 display / non-display

  • 1995.04
    -
    1999.03

    Kyushu University   Faculty of Pharmaceutical Science  

 

Published Papers 【 display / non-display

  • The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway.

    Tsuru A, Hamazaki Y, Tomida S, Ali MS, Kage-Nakadai E

    Bioscience, biotechnology, and biochemistry  2021.12  [Refereed]

    DOI PubMed

  • Seroepidemiological survey on pigs and cattle for novel K88 (F4)-like colonization factor detected in human enterotoxigenic Escherichia coli

    Yoshihiko Tanimoto, Miyoko Inoue, Kana Komatsu, Atsuyuki Odani, Takayuki Wada, Eriko Kage-Nakadai, Yoshikazu Nishikawa

    Cambridge University Press (CUP) Epidemiology and Infection    1 - 21 2021.12  [Refereed]

    DOI

  • Nonpathogenic Cutibacterium acnes Confers Host Resistance against Staphylococcus aureus.

    Tsuru A, Hamazaki Y, Tomida S, Ali MS, Komura T, Nishikawa Y, Kage-Nakadai E

    Microbiology spectrum  9 ( 2 ) e0056221 2021.10  [Refereed]

     View Summary

    Cutibacterium acnes is a human skin-resident bacterium. Although C. acnes maintains skin health by inhibiting invasion from pathogens like Staphylococcus aureus, it also contributes to several diseases, including acne. Studies suggest that differences in genetic background may explain the diverse phenotypes of C. acnes strains. In this study, we investigated the effects of C. acnes strains on the Caenorhabditis elegans life span and observed that some strains shortened the life span, whereas other strains, such as strain HL110PA4, did not alter it. Next, we assessed the effects of C. acnes HL110PA4 on host resistance against S. aureus. The survival time of C. acnes HL110PA4-fed wild-type animals was significantly longer than that of Escherichia coli OP50 control bacterium-fed worms upon infection with S. aureus. Although the survival times of worms harboring mutations at the daf-16/FoxO and skn-1/Nrf2 loci were similar to those of wild-type worms after S. aureus infection, administration of C. acnes failed to improve survival times of tir-1/SARM1, nsy-1/mitogen-activated protein kinase kinase kinase (MAPKKK), sek-1/mitogen-activated protein kinase kinase (MAPKK), and pmk-1/p38 mitogen-activated protein kinase (MAPK) mutants. These results suggest that the TIR-1 and p38 MAPK pathways are involved in conferring host resistance against S. aureus in a C. acnes-mediated manner. IMPORTANCE Cutibacterium acnes is one of the most common bacterial species residing on the human skin. Although the pathogenic properties of C. acnes, such as its association with acne vulgaris, have been widely described, its beneficial aspects have not been well characterized. Our study classifies C. acnes strains based on its pathogenic potential toward the model host C. elegans and reveals that the life span of C. elegans worms fed on C. acnes was consistent with the clinical association of C. acnes ribotypes with acne or nonacne. Furthermore, nonpathogenic C. acnes confers host resistance against the opportunistic pathogen Staphylococcus aureus. Our study provides insights into the impact of C. acnes on the host immune system and its potential roles in the ecosystem of skin microbiota.

    DOI PubMed

  • Bacillus subtilis var. natto increases the resistance of Caenorhabditis elegans to gram-positive bacteria

    Katayama R., Matsumoto Y., Higashi Y., Sun S., Sasao H., Tanimoto Y., Nishikawa Y., Kage-Nakadai E.

    JOURNAL OF APPLIED MICROBIOLOGY  2021.06  [Refereed]

    DOI

  • Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans.

    Ito A, Zhao Q, Tanaka Y, Yasui M, Katayama R, Sun S, Tanimoto Y, Nishikawa Y, Kage-Nakadai E

    Biogerontology  22 ( 1 ) 119 - 131 2021.02  [Refereed]

     View Summary

    Accumulating studies have argued that the mitochondrial unfolded protein response (UPRmt) is a mitochondrial stress response that promotes longevity in model organisms. In the present study, we screened an off-patent drug library to identify compounds that activate UPRmt using a mitochondrial chaperone hsp-6::GFP reporter system in Caenorhabditis elegans. Metolazone, a diuretic primarily used to treat congestive heart failure and high blood pressure, was identified as a prominent hit as it upregulated hsp-6::GFP and not the endoplasmic reticulum chaperone hsp-4::GFP. Furthermore, metolazone specifically induced the expression of mitochondrial chaperones in the HeLa cell line. Metolazone also extended the lifespan of worms in a atfs-1 and ubl-5-dependent manner. Notably, metolazone failed to increase lifespan in worms with knocked-down nkcc-1. These results suggested that metolazone activates the UPRmt across species and prolongs the lifespan of C. elegans.

    DOI PubMed

display all >>

Books etc 【 display / non-display

  • Brenner’s Encyclopedia of Genetics 2nd edition, Vol 2.

    Kage-Nakadai E. and Mitani S. (Part: Joint Work )

    Academic Press  2013.02

     View Summary

    遺伝学について幅広い分野をカバーした英文百科事典。医学、生命科学分野の学生や関連職業従事者対象。

Conference Activities & Talks 【 display / non-display

  • Host resistance to S. aureus conferred by C. acnes in C. elegans

    Ayano Tsuru, Yumi Hamazaki, Shuta Tomida, Mohammad Shaokat Ali, Tomomi Komura, Yoshikazu Nishikawa, Eriko Kage-Nakadai

    第44回日本分子生物学会年会  2021.12 

  • Conferring host resistance to Staphylococcus aureus by Cutibacterium acnes

    Ayano Tsuru, Yumi Hamazaki, Shuta Tomida, Tomomi Komura, Yoshikazu Nishikawa, Eriko Kage-Nakadai

    World Microbe Forum 2021  2021.06 

  • Molecular mechanisms underlying resistance to Gram-positive bacteria conferred by Bacillus subtilis var. natto in the Caenorhabditis elegans alternative model host

    Rina Katayama, Yumi Matsumoto, Yukina Higashi, Honoka Sasao, Yoshihiko Tanimoto, Simo Sun, Yoshikazu Nishikawa, Eriko Kage-Nakadai

    第93回日本細菌学会総会  2021.03 

  • Molecular mechanisms underlying resistance to Gram-positive bacteria conferred by Bacillus subtilis var. natto in the Caenorhabditis elegans alternative model host

    Rina Katayama, Yumi Matsumoto, Yukina Higashi, Honoka Sasao, Yoshihiko Tanimoto, Simo Sun, Yoshikazu Nishikawa, Eriko Kage-Nakadai

    第43回日本分子生物学会年会  2020.12 

  • Functional analysis of Hcp gene that constitutes type VI secretion systems and comprehensive screening of inflammatory suppression genes of diffusely adherent Escherichia coli isolated from healthy carrier.

    Atsuyuki Odani, Yoshihiko Tanimoto, Ayana Takaura, Tomomi Komura, Eriko Kage-Nakadai, Yoshikazu Nishikawa

    第43回 日本分子生物学会年会  2020.12 

display all >>