NISHIMURA Takahiro

写真a

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Title

Professor

Laboratory location

Sugimoto Campus

Degree 【 display / non-display

  • Kyoto University -  Doctor (Engineering)

Research Areas 【 display / non-display

Organic chemistry

Research subject summary 【 display / non-display

  • Transition metal-catalyzed functionalization of aromatic compounds via C-H bond activation has realized the step-economy synthesis of useful compounds. In particular, an ortho-selective functionalization has been achieved by use of directing groups, and in the past few decades, many catalytic systems for the C-H bond activation have been developed. We are interested in development of atom-economical organic transformations to realize stereoselective synthesis of useful organic molecules.

Research Interests 【 display / non-display

asymmetric synthesis, organic chemistry, catalysis

Association Memberships 【 display / non-display

  • American Chemical Society

Awards & Honors 【 display / non-display

  • Banyu Chemist Award

    2010  

  • Incentive Award in Synthetic Organic Chemistry, Japan

    2008  

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Science   Molecular Materials Science Course   Professor  

Graduate School 【 display / non-display

  •  
    -
    2001.03

    Kyoto University  Graduate School, Division of Engineering 

  •  
    -
    1996.03

    Kyoto University  Graduate School, Division of Engineering 

Graduating School 【 display / non-display

  • 1989.04
    -
    1994.03

    Kyoto University   Faculty of Engineering  

 

Published Papers 【 display / non-display

  • Iridium‐Catalyzed Asymmetric Hydroarylation of Chromene Derivatives with Aromatic Ketones: Enantioselective Synthesis of 2‐Arylchromanes

    Kana Sakamoto, Takahiro Nishimura

    Advanced Synthesis & Catalysis  2019.01  [Refereed]

  • Iridium-Catalyzed Direct Hydroarylation of Glycals via C−H Activation: Ligand-Controlled Stereoselective Synthesis of α- and β‐C‐Glycosyl Arenes

    Kana Sakamoto, Masaki Nagai, Yusuke Ebe, Hideki Yorimitsu, Takahiro Nishimura

    ACS Catalysis  9 ( 2 ) 1347 - 1352 2019.01  [Refereed]

  • Iridium-Catalyzed Sequential sp(3) C-H Alkylation of an N-Methyl Group with Alkenes Towards the Synthesis of alpha-Substituted Amines

    Hattori Hiroshi, Nishimura Takahiro

    ADVANCED SYNTHESIS & CATALYSIS  360 ( 24 ) 4827 - 4831 2018.12  [Refereed]

    DOI

  • Hydroxoiridium-Catalyzed sp(3) C-H Alkylation of Indoline Derivatives with Terminal Alkenes

    Nakamura Ikumi, Yamauchi Daisuke, Nishimura Takahiro

    ASIAN JOURNAL OF ORGANIC CHEMISTRY  7 ( 7 ) 1347 - 1350 2018.07  [Refereed]

    DOI

  • Iridium/Chiral Diene-Catalyzed Enantioselective (3+2) Annulation of Aromatic Ketimines with 1,3-Enynes via C-H Activation

    Nagamoto Midori, Sakamoto Kana, Nishimura Takahiro

    ADVANCED SYNTHESIS & CATALYSIS  360 ( 4 ) 791 - 795 2018.02  [Refereed]

    DOI

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Books etc 【 display / non-display

  • ロジウム,有機合成実験法ハンドブック第2版

    西村 貴洋 (Part: Single Work )

    有機合成化学協会  2015

  • Preparation of Fluoroalkylated-Pyridines

    NISHIMURA Takahiro (Part: Single Work )

    Handbook on Fluorous Chemistry; Eds. J. A. Gladysz, D. P. Curran, I. H. Horváth, Wiley-VCH  2004

Review Papers (Misc) 【 display / non-display

  • 「化学のフロンティア2003」,アルコキシパラジウムを経る新規触媒反応系の開発:酸素酸化と炭素—炭素結合開裂反応

    西村貴洋,植村 榮

    化学と工業  56   117 - 120 2003  [Refereed]  [Invited]

Conference Activities & Talks 【 display / non-display

  • Iridium-Catalyzed Enantioselective Hydroarylation of Chromene Derivatives

    Kana Sakamoto, Takahiro Nishimura

    10th OCARINA International Symposium  2019.03 

  • Acid-Catalyzed Chirality-Transferring Intramolecular Friedel-Crafts Reaction of α-Hydroxy-α-alkenylsilanes

    Shunichi Nakamura, Takahiro Nishimura, K. Sakaguchi

    10th OCARINA International Symposium  2019.03 

  • Iridium-Catalyzed sp3 C−H bond Alkylation of Indoline Delivatives with Terminal Alkenes

    Ikumi Nakamura, Masaki Nagai, Takahiro Nishimura

    10th OCARINA International Symposium  2019.03 

  • Iridium-Catalyzed Direct sp3 C–H Alkylation of Aminoalkyl Groups with Alkenes

    Hattori Hattori, Ikumi Nakamura, Daisuke Yamauchi, Takahiro Nishimura

    The 14th International Kyoto Conference on New Aspects of Organic Chemistry  2018.11 

  • Ir-Catalyzed Enantioselective Hydroarylation of 2H-Chromene with Aromatic Ketones

    Kana Sakamoto, Takahiro Nishimura

    The 14th International Kyoto Conference on New Aspects of Organic Chemistry  2018.11 

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Grant-in-Aid for Scientific Research 【 display / non-display

  • Development of Stereoselective Hydrofuctionalizations

    Project/Area Number : 15H03810  Grant-in-Aid for Scientific Research(B) Representative

    Project Year :

    2015.04
    -
    2018.03
     

  • Asymmetric construction of a stereogenic carbon center substituted with aryl groups

    Project/Area Number : 24550117  Grant-in-Aid for Scientific Research(C) Representative

    Project Year :

    2012.04
    -
    2015.03
     

    Partaker : EBE Yusuke, NAGAMOTO Midori, TAKECHI Ryosuke, HATANO Miyuki, YAMAUCHI Daisuke, NAGAI Tomotaka, FUJIMOTO Hiroto, NOISHIKI Akira, TAKIGUCHI Yuka, MAEDA Yuko

     View Summary

    We have developed Rh-catalyzed arylation methods by use of arylboron reagents for the synthesis of chiral compounds having a stereogenic carbon center that is substituted with aryl groups. The use of chiral diene ligands base on a tetrafluorobenzobarrelene (tfb) framework was found to be effective in catalyzing the arylation reaction with high enantioselectivity. It was also found that Ir-catalyzed annulation of aromatic imines with 1,3-dienes or alkynes proceeds via C-H bond activation with high stereoselectivity.

  • Development ofπ-Accepting Chiral Ligands and their Application to Catalytic Asymmetric Reactions

    Project/Area Number : 22750090  Grant-in-Aid for Young Scientists(B) Representative

    Project Year :

    2010
    -
    2011
     

     View Summary

    We have developed new chiral diene ligands base on tetrafluorobenzobarrelene(tfb) framework. Their rhodium complexes displayed high catalytic activity and enantioselectivity in the addition of arylboron reagents to unsaturated bonds. Iridium/chiral tfb complexes were also found to display high catalytic activity in the asymmetric 1, 6-addition of arylboroxines to dienones giving the corresponding addition products in high yields with high enantioselectivity.

  • Advanced Control of Catalytic Activity and Stereoselectivity in Catalytic Asymmetric Reactions

    Project/Area Number : 19105002  Grant-in-Aid for Scientific Research(S) Partaker / Other

    Project Year :

    2007
    -
    2010
     

    Partaker : SHIRAKAWA Eiji, NISHIMURA Takahiro, SHINTANI Ryo

     View Summary

    One of the most important subjects in studying asymmetric catalysis is development of new chiral ligands which have both high catalytic activity and high enantioselectivity. We have successfully developed an entirely new type of chiral ligands which have olefins as coordinating functionalities to metal catalysts. Among them, chiral diene ligands showed great performance in terms of both catalytic activity and enantioselectivity in rhodium- and iridium-catalyzed asymmetric carbon-carbon bond forming reactions.

  • Selective Transformations of Cycloalkanes via Carbon-Carbon Bond Cleavage

    Project/Area Number : 17065013  Grant-in-Aid for Scientific Research on Priority Areas Representative

    Project Year :

    2005
    -
    2008
     

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Charge of on-campus class subject 【 display / non-display

  • Basic Organic Chemistry I

    (2018) University, General education courses