NISHIMURA Takahiro

写真a

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Title

Professor

Laboratory location

Sugimoto Campus

Degree 【 display / non-display

  • Kyoto University -  Doctor (Engineering)

Research Areas 【 display / non-display

Organic chemistry, Synthetic chemistry

Research subject summary 【 display / non-display

  • Transition metal-catalyzed functionalization of aromatic compounds via C-H bond activation has realized the step-economy synthesis of useful compounds. In particular, an ortho-selective functionalization has been achieved by use of directing groups, and in the past few decades, many catalytic systems for the C-H bond activation have been developed. We are interested in development of atom-economical organic transformations to realize stereoselective synthesis of useful organic molecules.

Research Interests 【 display / non-display

organic chemistry, catalysis, asymmetric synthesis, Transition-Metal-Catalysts , Atom Econimy, Green Chemistry

Association Memberships 【 display / non-display

  • American Chemical Society

Awards & Honors 【 display / non-display

  • Banyu Chemist Award

    2010  

  • Incentive Award in Synthetic Organic Chemistry, Japan

    2008  

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Science   Molecular Materials Science Course   Professor  

Graduate School 【 display / non-display

  • 1997.10
    -
    2001.03

    Kyoto University  Graduate School, Division of Engineering 

  • 1994.04
    -
    1996.03

    Kyoto University  Graduate School, Division of Engineering 

Graduating School 【 display / non-display

  • 1989.04
    -
    1994.03

    Kyoto University   Faculty of Engineering  

 

Published Papers 【 display / non-display

  • Enantioselective synthesis of 3-substituted dihydrobenzofurans through iridium-catalyzed intramolecular hydroarylation

    Sakamoto Kana, Nishimura Takahiro

    ORGANIC & BIOMOLECULAR CHEMISTRY  19 ( 3 ) 684 - 690 2021.01  [Refereed]

    DOI PubMed

  • Enantioselective Synthesis of Chiral Indane Derivatives by RhodiumCatalyzed Addition of Arylboron Reagents to Substituted Indenes

    Umeda Moeko, Noguchi Hikaru, Nishimura Takahiro

    ORGANIC LETTERS  22 ( 24 ) 9597 - 9602 2020.12  [Refereed]

    DOI PubMed

  • Synthesis of Allene-Containing Apocarotenoids by Cross-Coupling Strategy

    Sakaguchi Kazuhiko, Nishioka Yuto, Kinashi Naoto, Yukihira Nao, Shinada Tetsuro, Nishimura Takahiro, Hashimoto Hideki, Katsumura Shigeo

    SYNTHESIS-STUTTGART  52 ( 20 ) 3007 - 3017 2020.10  [Refereed]

    DOI

  • Iridium-catalyzed Annulation of alpha,beta-Unsaturated Amides with Electron-deficient Conjugated Dienes

    Murakami Kotone, Nagamoto Midori, Nishimura Takahiro

    公益社団法人 日本化学会 CHEMISTRY LETTERS  49 ( 6 ) 732 - 735 2020.06  [Refereed]

     View Summary

    <p>Annulation of α,β-unsaturated amides with electron-deficient 1,3-dienes gave 5,6-dihydropyridin-2(1<i>H</i>)-ones in the presence of a hydroxoiridium catalyst. The reaction proceeded via direct C–H alkylation of acrylamides with conjugated dienes, followed by intramolecular aza-Michael addition, thus giving dihydropyridinones stereoselectively in good yields.</p>

    DOI CiNii

  • Rhodium-catalyzed asymmetric addition of arylboronic acids to 2H-chromenes leading to 3-arylchromane derivatives

    Umeda Moeko, Sakamoto Kana, Nagai Tomotaka, Nagamoto Midori, Ebe Yusuke, Nishimura Takahiro

    CHEMICAL COMMUNICATIONS  55 ( 79 ) 11876 - 11879 2019.10  [Refereed]

    DOI PubMed

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Books etc 【 display / non-display

  • ロジウム,有機合成実験法ハンドブック第2版

    西村 貴洋 (Part: Single Work )

    有機合成化学協会  2015

  • Preparation of Fluoroalkylated-Pyridines

    NISHIMURA Takahiro (Part: Single Work )

    Handbook on Fluorous Chemistry; Eds. J. A. Gladysz, D. P. Curran, I. H. Horváth, Wiley-VCH  2004

Review Papers (Misc) 【 display / non-display

  • 「化学のフロンティア2003」,アルコキシパラジウムを経る新規触媒反応系の開発:酸素酸化と炭素—炭素結合開裂反応

    西村貴洋,植村 榮

    化学と工業  56   117 - 120 2003  [Refereed]  [Invited]

Conference Activities & Talks 【 display / non-display

  • イリジウム触媒による糖類を用いたメチルケトンのα-アルキル化反応

    柘植康希, 久保田駿一, 坂本佳那, 西村貴洋, 北山健司

    日本化学会第101春季年会  2021.03 

  • イリジウム触媒を用いたsp3 C-H活性化を経るα-トリフルオロメチルスチレンの不斉ヒドロアルキル化反応

    山内大輔, 中村威久海, 西村貴洋

    日本化学会第101春季年会  2021.03 

  • イリジウム触媒を用いたN−スルホニルケチミンのC–Hアリル化反応

    矢部亮太, 西村貴洋

    日本化学会第101春季年会  2021.03 

  • イリジウム触媒を用いたN-メチル基C–H結合のα,ω-ジエンによる直接アルキル化を経る環化反応

    田中克昌, 矢部亮太, 服部大志, 西村貴洋

    日本化学会第101春季年会  2021.03 

  • フェノールが連結したアレニルシランの酸化的分子内環化

    岸本遼真, 坂口和彦, 西村貴洋

    日本化学会第101春季年会  2021.03 

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Grant-in-Aid for Scientific Research 【 display / non-display

  • Development of Stereoselective Hydrofuctionalizations

    Project/Area Number : 15H03810  Grant-in-Aid for Scientific Research(B) Representative

    Project Year :

    2015.04
    -
    2018.03
     

  • Asymmetric construction of a stereogenic carbon center substituted with aryl groups

    Project/Area Number : 24550117  Grant-in-Aid for Scientific Research(C) Representative

    Project Year :

    2012.04
    -
    2015.03
     

    Partaker : EBE Yusuke, NAGAMOTO Midori, TAKECHI Ryosuke, HATANO Miyuki, YAMAUCHI Daisuke, NAGAI Tomotaka, FUJIMOTO Hiroto, NOISHIKI Akira, TAKIGUCHI Yuka, MAEDA Yuko

     View Summary

    We have developed Rh-catalyzed arylation methods by use of arylboron reagents for the synthesis of chiral compounds having a stereogenic carbon center that is substituted with aryl groups. The use of chiral diene ligands base on a tetrafluorobenzobarrelene (tfb) framework was found to be effective in catalyzing the arylation reaction with high enantioselectivity. It was also found that Ir-catalyzed annulation of aromatic imines with 1,3-dienes or alkynes proceeds via C-H bond activation with high stereoselectivity.

  • Development ofπ-Accepting Chiral Ligands and their Application to Catalytic Asymmetric Reactions

    Project/Area Number : 22750090  Grant-in-Aid for Young Scientists(B) Representative

    Project Year :

    2010
    -
    2011
     

     View Summary

    We have developed new chiral diene ligands base on tetrafluorobenzobarrelene(tfb) framework. Their rhodium complexes displayed high catalytic activity and enantioselectivity in the addition of arylboron reagents to unsaturated bonds. Iridium/chiral tfb complexes were also found to display high catalytic activity in the asymmetric 1, 6-addition of arylboroxines to dienones giving the corresponding addition products in high yields with high enantioselectivity.

  • Advanced Control of Catalytic Activity and Stereoselectivity in Catalytic Asymmetric Reactions

    Project/Area Number : 19105002  Grant-in-Aid for Scientific Research(S) Partaker / Other

    Project Year :

    2007
    -
    2010
     

    Partaker : SHIRAKAWA Eiji, NISHIMURA Takahiro, SHINTANI Ryo

     View Summary

    One of the most important subjects in studying asymmetric catalysis is development of new chiral ligands which have both high catalytic activity and high enantioselectivity. We have successfully developed an entirely new type of chiral ligands which have olefins as coordinating functionalities to metal catalysts. Among them, chiral diene ligands showed great performance in terms of both catalytic activity and enantioselectivity in rhodium- and iridium-catalyzed asymmetric carbon-carbon bond forming reactions.

  • Selective Transformations of Cycloalkanes via Carbon-Carbon Bond Cleavage

    Project/Area Number : 17065013  Grant-in-Aid for Scientific Research on Priority Areas Representative

    Project Year :

    2005
    -
    2008
     

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Charge of on-campus class subject 【 display / non-display

  • Basic Organic Chemistry I

    (2019) University, General education courses