NISHIKAWA Keisuke

写真a

Search Institutional Repository


Title

Assistant Professor

Laboratory location

Sugimoto Campus

Homepage URL

http://www.sci.osaka-cu.ac.jp/chem/org2/index.html

Mail Address

E-mail address

Degree 【 display / non-display

  • Hokkaido University -  Docter ( Environmental Science )

  • Hokkaido University -  Master ( Environmetal Earth Science )

  • Hokkaido University -  Bachelor ( Engineering )

Research Areas 【 display / non-display

Organic chemistry, Synthetic chemistry, Biomolecular chemistry

Research subject summary 【 display / non-display

  • My research interests include the total synthesis of bioactive natural products, its biological activities, the structure-activity relationship study and new synthesis method for the total synthesis.

Research Interests 【 display / non-display

Organic Synthesis, Natural Product Synthesis, Alkaloid, Terpenoid, Nitrogen-containing Spirocyclic Compound, Cytotoxic Polyether

Research Career 【 display / non-display

  • Synthetic Studies on Diterpenoid Possessing Strong Antifouling Activity

    (Collaboration in Japan) Project Year :

    2014.04
    -
    Today

    Keyword in research subject:  Diterpenoid

  • Synthesis of Natural Antifouling Comopound for the Development of Environmental Friendly Antifouling Agent

    (Collaboration in Organization) Project Year :

    2006.04
    -
    2010.06

    Keyword in research subject:  Antifouling Compound

Association Memberships 【 display / non-display

  • The Chemical Society of Japan

  • The Society of Synthetic Organic Chemistry, Japan

  • The Pharmaceutical Society of Japan

  • Japanese Society for Chemical Biology

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Science   Molecular Materials Science Course   Assistant Professor  

Career 【 display / non-display

  • 2012.04
    -
    2013.03

    Kyushu University   Institute for Materials Chemistry and Engineering   Research Assistant Professor

  • 2010.07
    -
    2012.03

    Kyushu University   Institute for Materials Chemistry and Engineering   Post-doctoral Fellow

  • 2008.11
    -
    2009.03

    Hokkaido University   Research Assistant

  • 2006.04
    -
    2007.03

    Hokkaido University   Research Assistant

Graduate School 【 display / non-display

  • 2006.04
    -
    2010.06

    Hokkaido University  Graduate School, Division of Environmental Science 

  • 2004.04
    -
    2006.03

    Hokkaido University  Graduate School, Division of Earth Environmental Science and Technology 

Graduating School 【 display / non-display

  • 2000.04
    -
    2004.03

    Hokkaido University   Faculty of Engineering  

 

Published Papers 【 display / non-display

  • Antioxidants from the Brown Alga Dictyopteris undulata

    Kumagai Momochika, Nishikawa Keisuke, Matsuura Hiroshi, Umezawa Taiki, Matsuda Fuyuhiko, Okino Tatsufumi

    MDPI MOLECULES  23 ( 5 ) 1214 - 1214 2018.05  [Refereed]

     View Summary

    An investigation of anti-oxidative compounds from the brown alga Dictyopteris undulata has led to the isolation and identification of isozonarol, isozonarone, chromazonarol, zonaroic acid and isozonaroic acid. Their structures were identified by comparison of MS and NMR spectra. Full NMR assignment and absolute configuration of isozonaroic acid are described. Isozonarol showed the most potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity among the compounds isolated.

    DOI PubMed CiNii

  • Formal total synthesis of histrionicotoxin alkaloids via Hg(OTf)2-catalyzed cycloisomerization and SmI2-induced ring expansion

    Matsumura Kunihiro, Nishikawa Keisuke, Yoshida Hiroaki, Doe Matsumi, Morimoto Yoshiki

    RSC ADVANCES  8 ( 21 ) 11296 - 11303 2018.03  [Refereed]

    DOI

  • Asymmetric Total Synthesis of (-)-Stemonamine and Its Stereochemical Stability

    Fujita Satoshi, Nishikawa Keisuke, Iwata Takayuki, Tomiyama Taishi, Ikenaga Hiroshi, Matsumoto Kenji, Shindo Mitsuru

    CHEMISTRY-A EUROPEAN JOURNAL  24 ( 7 ) 1539 - 1543 2018.02  [Refereed]

    DOI PubMed

  • Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages

    Kumagai Momochika, Watanabe Akio, Yoshida Izumi, Mishima Takashi, Nakamura Munetomo, Nishikawa Keisuke, Morimoto Yoshiki

    公益社団法人 日本薬学会  41 ( 1 ) 132 - 137 2018.01  [Refereed]

     View Summary

    <p>Anti-inflammatory activity of aculeatin and toddaculin, which are coumarins with a similar structure isolated from <i>Toddalia asiatica</i> (L.) LAM., was evaluated using lipopolysaccharide (LPS)-stimulated RAW264 mouse macrophage cells. Both aculeatin and toddaculin significantly inhibited mRNA expression of inflammatory mediators and nitric oxide production. Furthermore, Toddaculin suppressed LPS-induced phosphorylation of p38 and extracellular signal-regulated kinase (ERK)1/2 and inhibited LPS-induced activation of nuclear factor-kappaB (NF-κB). However, aculeatin did not exhibit such effects, suggesting that aculeatin and toddaculin suppress LPS-induced inflammation of RAW264 cells <i>via</i> different mechanisms. The cellular uptake of these compounds was also evaluated. Toddaculin was detected in RAW264 cells after 4 and 24 h. However, aculeatin levels were not observed in RAW264 cells at all incubation intervals. These results indicate that de-epoxidation of a prenyl group can increase hydrophobicity of molecule and is thought to accelerate cellular uptake and/or interactions with the phospholipid bilayers of cell membranes.</p>

    DOI CiNii

  • Total Syntheses of Lepadiformine Marine Alkaloids with Enantiodivergency, Utilizing Hg(OTf)2-Catalyzed Cycloisomerization Reaction and their Cytotoxic Activities

    Nishikawa Keisuke, Yamauchi Kengo, Kikuchi Seiho, Ezaki Shinnosuke, Koyama Tomoyuki, Nokubo Haruka, Matsumura Kunihiro, Kodama Takeshi, Kumagai Momochika, Morimoto Yoshiki

    CHEMISTRY-A EUROPEAN JOURNAL  23 ( 40 ) 9535 - 9545 2017.07  [Refereed]

    DOI

display all >>

Conference Activities & Talks 【 display / non-display

  • Synthesis of Tetrodotoxin Framework

    Takayuki Noguchi、Rina Takeda、Takahiro Maruyama、Yusuke Araki、Keisuke Nishikawa、Yoshiki Morimoto

    The 99th Annual Meeting of The Chemical Society of Japan  2019.03 

  • Total Synthesis of Histrionicotoxin 235A

    Kunihiro Matsumura, Hiroaki Yoshida, Tomoyuki Koyama, Toshiki Niwa, Keisuke Nishikawa, Yoshiki Morimoto

    The 14th International Kyoto Conference on New Aspects of Organic Chemistry ( IKCOC-14 )  (Rihga Royal Hotel Kyoto)  2018.11 

  • Total Synthesis of Saiyacenol A

    Keisuke Nishikawa、Kento Nishikibe、Yoshiki Morimoto

    2018.08 

  • Total Synthesis of Histrionicotoxine 235A

    Kunihiro Matsumura、Keisuke Nishikawa、Hiroaki Yoshida、Mai Takami、Toshiki Niwa、Tomoyuki Koyama、Yoshiki Morimoto

    2018.08 

  • Synthetic Study of Histrionicotoxin Alkaloid

    Kunihiro Matsumura、Hiroaki Yoshida、Mai Takami、Tomoyuki Koyama、Keisuke Nishikawa、Yoshiki Morimoto

    2018.05 

display all >>

Grant-in-Aid for Scientific Research 【 display / non-display

  • Development of the Asymmetric Cycloisomerization Reaction to Directly Provide Nitrogen-containing Spiro Cyclic Products : New Strategy for the Synthesis of Alkaloids

    Grant-in-Aid for Scientific Research(C) Representative

    Project Year :

    2019.04
    -
    2022.03
     

 

Charge of on-campus class subject 【 display / non-display

  • Practice in Organic Chemistry 1

    (2018) University, Special course

  • Practice in Organic Chemistry 2

    (2018) University, Special course

  • Advanced Research Course for Master's Thesis of Science

    (2018) Graduate school, Special course

  • Senior Thesis Project

    (2018) University, Special course

  • Advanced Experiments in Chemistry III

    (2018) University, Special course

Other educational activity and Special note 【 display / non-display

  • Contribution to FD activities

    (2017)

 

Social Contribution 【 display / non-display

  • Osaka City University Open Campus 2018

    (Osaka City University)

    Role : Lecturer, Advisor, Informant, Demonstrator, Report writing

     Audience : High school students, Teachers, Guardians, General 

    2018.08
     
     

    Sponsor, Organizer, Publisher : Osaka City University 

  • Osaka City University Open Campus 2017

    (Osaka City University)

    Role : Editer, Lecturer, Advisor, Informant, Planner, Organizing Member, Demonstrator, Report writing

     Audience : High school students, Teachers, Guardians, General 

    2017.08
     
     

    Sponsor, Organizer, Publisher : Osaka City University 

 

Foreigner acceptance 【 display / non-display

  • Academic year : 2018

     View Details

    Number of foreigners accepted
    1
    Number of International Students
    1

    マレーシア