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Laboratory location

Sugimoto Campus

Research Areas 【 display / non-display

Bioinorganic Chemistry, Coordination Chemistry

Research Interests 【 display / non-display

Engneering of Natural protein, Thermophilic bacteria, Sensor Protein, Protein engineering, Protein from thermophilic Bacterium, Metal cluster, Metal Complex

Research Career 【 display / non-display

  • Development of novel bio-sensing mechanism using signal transducer protein

    (Individual) Project Year :


    Keyword in research subject:  Signal Transducer, Biosensor, Bioelectrochemistry

  • Exploration of chemical reactions driven by near infrared light

    (Individual) Project Year :


    Keyword in research subject:  NIR responsive CO releasing molecule, Biocompatible Prussian Blue

  • Development of functional composites consisting of proteins and metal complexes

    (Individual) Project Year :


    Keyword in research subject:  hollow proteins, proteins from thermophiles, electron transfer proteins, metal complexes

  • Development of functional materials exploiting proteins from thermophilic bacteria

    (Individual) Project Year :


    Keyword in research subject:  Thermophilus, Functional Material, Metalloprotein

Education summary 【 display / non-display

  • I'm in charge of lectures and lab experiments for undergraduates about inorganic chemistry, coordination chemistry, organometallic chemistry, bioinorganic chemistry. My lectures about group theory to understand the molecular symmetry of metal complexes and their reaction mechanism are given to graduate students.

Association Memberships 【 display / non-display

  • American Chemical Society

  • The Chemical Society of Japan

  • The Biophysiocal Society of Japan

  • The Electrochemical Society of Japan

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Science   Molecular Materials Science Course   Professor  

Career 【 display / non-display

  • 2015.04

    Osaka City University  

  • 1996

    Japan Advanced Institute for Science and Technology  

Graduating School 【 display / non-display


    Osaka University   Faculty of Engineering   Department of Applied Chemistry


Published Papers 【 display / non-display

  • CO Release from N,C,S-Pincer Iron(III) Carbonyl Complexes Induced by Visible-to-NIR Light Irradiation: Mechanistic Insight into Effects of Axial Phosphorus Ligands

    T. Nakae, M. Hirotsu, H. Nakajima

    Inorg. Chem.  57 ( 14 ) 8615 - 8626 2018.08  [Refereed]

  • The Arrangement of Two N-Heterocyclic Carbene Moieties in Palladium Pincer Complexes Affects Their Catalytic Activity towards Suzuki–Miyaura Cross-Coupling Reactions in Water

    Yosuke Imanaka, Naotoshi Shiomoto, Mako Tamakai, Yuri Maeda, Hiroshi Nakajima, Takanori Nishioka

    Bull. Chem. Soc. Jpn.   90   59 - 67 2017  [Refereed]

  • Visible-light-induced release of CO by thiolate iron(III) carbonyl complexes bearing N,C,S-pincer ligands

    T. Nakae, M. Hirotsu, S. Aono, H. Nakajima

    Dalton Trans.  45 ( 41 ) 16153 - 16156 2016.11  [Refereed]

  • Creation of a Thermally Tolerant Peroxidase

    Y. Watanabe, H. Nakajima

    Methods in Enzymology  580   455 - 470 2016.03  [Refereed]

  • Construction of an enterobactin analogue with symmetrically arranged monomer subunits of ferritin

    Nakajima H., Kondo M., Nakane T., Abe S., Nakao T., Watanabe Y., Ueno T.

    Chem. Commun.  51   16609 - 16612 2015.12

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Books etc 【 display / non-display

  • Creation of CO releasing complex sensitive to NIR light

    H. Nakajima (Part: Single Work )


  • Creation of CO releasing molecule triggered by NIR light irradiation

    H. Nakajima, M. Hirotsu (Part: Joint Work )


Conference Activities & Talks 【 display / non-display

  • Synthesis, Properties, and Catalytic Ability of Water-soluble Nickel(II) Complexes with Tridentate or Bidentate N-Heterocyclic Carbene Ligands Containing Pyridine and Sugar Moieties

    M. Tamaki, H. Nakajima, T. Nishioka

    The 25th International SPACC Symposium  2018.11 

  • Development of Trinuclear Complexes for Molecular Sensing

    N. Yabune, H. Nakajima, T. Nishioka

    The 25th International SPACC Symposium  2018.11 

  • Development of Catalysts for Carbon-Sulfur Coupling Reactions Using Pd N-Heterocyclic Carbenes Complexes

    M. Takasaki, H. Nakajima, T. Nishioka

    The 25th International SPACC Symposium  2018.11 

  • “NIR responsive CO releasing iron complex aiming at biological use

    H. Nakajima, M. Hirotsu, T. Nakae, T. Kusumoto  [Invited]

    Internatinal Coordicanation Chemistry Conference (ICCC) 201  2018.07 

  • Conversion of electron transfer proteins to Biofunctional Materials

    H. Nakajima, M. Hirotsu, T. Nishioka, T. Nakae  [Invited]

    The 11th Japanese-Russian Workshop on ”Open Shell Compounds and Molecular Spin Devices  2017.12 

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Grant-in-Aid for Scientific Research 【 display / non-display

  • Creation of a protein-based nano-carrier that releases drug molecules depending on specific protease

    Grant-in-Aid for challenging Exploratory Research Partaker / Other

    Project Year :


  • Signal transduction of a transcriptional activator by using dynamic interaction of electron transfer proteins

    Grant-in-Aid for Scientific Research on Innovative Areas Representative

    Project Year :


Other external funds procured 【 display / non-display

  • Signal Transduction Mechanism Inspired by Natural Sensor Protein

    Project Year :



Other educational activity and Special note 【 display / non-display

  • Improvement of educational methods


  • Contribution to internationalization


  • Contribution to internationalization


  • Improvement of educational methods


  • Class teacher


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