AZUMA Hideki

写真a

Institutional repository


Title

Lecturer

Laboratory location

Sugimoto Campus

Research Areas 【 display / non-display

Synthetic chemistry, Bio-related chemistry

Research Interests 【 display / non-display

antitumor, cyclodextrin, folic acid, anthraquinone, endocytosis

Research Career 【 display / non-display

  • Enhancing effect of the metabolite of 1'-acetoxychavicol acetate (ACA) on Photodynamic Therapy

    (Collaboration in Japan) Project Year :

    2014.04
    -
    Today

    Keyword in research subject:  Acetoxychavicol acetate, Glutathione, Photodynamic therapy

  • Combination effect of S-allyl-cysteine derivative and various anti-inflammatory agents on the suppression of macrophage activation

    (Collaboration in Japan) Project Year :

    2013.04
     
     

    Keyword in research subject:  Allylcysteine, macrophage, antiinflammation

  • Synthesis and bioactivity of the marine sphingolipids.

    (Individual) Project Year :

    2013.04
     
     

    Keyword in research subject:  Marine sphingolipid, Antitumor, Apoptosis

  • Lipase-catalyzed Preparation of Optically Active 1'-Acetoxychavicol Acetates and their Structure-Activity Relationships in Apoptotic Activity Against Human Leukemia HL-60 Cells

    (Collaboration in Organization) Project Year :

    2004.04
    -
    2005.03

    Keyword in research subject:  Lipase, Apoptosis

Association Memberships 【 display / non-display

  • The Chemical Society of Japan

  • The Society of Synthetic Organic Chemistry, Japan

Committee Memberships 【 display / non-display

  • 2012.04
    -
    Today

    The Society of Synthetic Organic Chemistry, Japan   Officer of Kansai Branch

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Engineering   Applied Chemistry and Bioengineering Course   Lecturer  

  • Osaka City University   Graduate School of Engineering   Applied Chemistry and Bioengineering Course   Lecturer  

 

Published Papers 【 display / non-display

  • Lipase-catalyzed Preparation of Optically Active 1'-Acetoxychavicol Acetates and their Structure-Activity Relationships in Apoptotic Activity Against Human Leukemia HL-60 Cells

    K. Miyasaka, T. Yokotani, T. Tachibana, A. Kojima-Yuasa, I. Matsui-Yuasa, K. Ogino

    Bioorg. Med. Chem.  14   1811 - 1818 2007

  • S-allyl-glutathione improves experimental liver fibrosis by regulating Kupffer cell activation in rats

    Takemura Shigekazu, Azuma Hideki, Osada-Oka Mayuko, Kubo Shoji, Shibata Toshihiko, Minamiyama Yukiko

    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY  314 ( 2 ) G150 - G163 2018.02  [Refereed]

    DOI

  • S-allyl-glutathione improves liver fibrosis by inhibition of excess M1-or M2-polarized macrophage in rats.

    Takemura Shigekazu, Minamiyama Yukiko, Azuma Hideki, Osada-Oka Mayuko, Kubo Shoji

    HEPATOLOGY  66   220A - 220A 2017.10  [Refereed]

  • Improved isolation procedure for shikonin from the root of the Chinese medicinal plant Lithospermum erythrorhizon and its solubilization with cyclodextrins

    Azuma Hideki, Li Jiawei, Youda Ryota, Suzuki Toshio, Miyamoto Kazuhide, Taniguchi Taizo, Nagasaki Takeshi

    JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS  3 ( 2 ) 58 - 63 2016.05  [Refereed]

    DOI

  • Improved isolation procedure for shikonin from the root of the Chinese medicinal plant Lithospermum erythrorhizon and its solubilization with cyclodextrins

    Hideki Azuma, Jiawei Li, Ryota Youda, Toshio Suzuki, Kazuhide Miyamoto, Taizo Taniguchi, Takeshi Nagasaki

    Journal of Applied Research on Medicinal and Aromatic Plants  in press 2016

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Conference Activities & Talks 【 display / non-display

  • Application of self-assembled vesicles prepared from anthraquinone-modified cyclodextrins as carriers of 1’-acetoxychavicol acetate and presentation of folic acid on the surfaces

    Hideki Azuma, Chisa Fukuda, Takeshi Nagasaki

    The 98th CSJ Annual Meeting  2018.03 

  • Study on melanoma selective uptake of kojic acid using its fluorescent labeled analogues

    Yasuhito Morishima, Takuya Oofuji, Hideki Azuma, Takeshi Nagasaki

    The 47th Congress of Heterocyclic Chemistry  2017.10 

  • Preparation of self-assembled vesicles from anthraquinone-modified cyclodextrin/1’-acetoxychavicol acetate complexes and presentation of folic acids on the vesicle surfaces

    Chisa Fukuda, Hideki AZUMA, Takeshi NAGASAKI

    The Society of Physical Organic Chemistry, Japan  2017.06 

  • Lipase-catalyzed optical resolution of shikonin/alkannin

    Hideki AZUMA, kyosuke Enomoto, Toshio SUZUKI, Taizo TANIGUCHI, Takeshi NAGASAKI

    The Society of Physical Organic Chemistry, Japan  2017.06 

  • Preparation of the water-soluble inclusion complex of coumaryl alcohol derivative with 2-hydroxypropyl-beta-cyclodextrin and its enhancing effect on photodynamic therapy

    Host−Guest Chemistry Symposium 2016  2016.06 

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Charge of on-campus class subject 【 display / non-display

  • Exercises in Applied Chemistry and Bioengineering A

    (2017) University, Special course

  • IT Exercises in Bioengineering

    (2017) University, Special course

  • Analytical Chemistry II

    (2017) University, Special course

Other educational activity and Special note 【 display / non-display

  • Contribution to FD activities

    (2011)

Educational activity record 【 display / non-display

  • Academic year : 2011

     View Details

    Number of instructed the graduation thesis
    3
    Number of graduation thesis reviews
    3
    Number of instructed the Master's Program (previous term)
    0
    Number of instructed the Master's Program (letter term)
    0
    Number of master's thesis reviews (chief)
    0
    Number of master's thesis reviews (vice-chief)
    0
    Number of doctoral thesis reviews (chief)
    0
    Number of doctoral thesis reviews (vice-chief)
    0
 

Theme of Possible Research Exchange 【 display / non-display

  • Synthese of the bioactive compounds of sphingolipids

    Research theme : Sphingolipuds are abundantly located in plasma membranes and composed of sphingosine, a fatty acid and a polar head group. We synthesize these analogs and investigate the bioactivities of them.

    Keyword : Sphingolipid, Ceramide, Sphingosine, Synthesis

     View Details

    Application fields / methods etc : For the significance of sphingolipids for skin function, we will contribute for product development in the cosmetic industry to elucidate the difference of activities by the structural features.