HIROTUNE Shinji

写真a

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Title

Professor

Laboratory location

Abeno Campus

Degree 【 display / non-display

  • Osaka University -  Doctor of Medical Science

Research Areas 【 display / non-display

Neuroscience

Research Interests 【 display / non-display

neuronal degeneration , neural development, intracellular transport

Research Career 【 display / non-display

  • Neuronal Development

    (Individual)

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Medicine   Basic Medicine Course   Professor  

Graduate School 【 display / non-display

  • 1989.04
    -
    1993.03

    Osaka University  Graduate School, Division of Medical Sciences 

Graduating School 【 display / non-display

  • 1981.04
    -
    1987.03

    Osaka City University   Faculty of Medicine  

 

Published Papers 【 display / non-display

  • シヌクレイン変異によるパーキンソン病の分子機構解明

    広常 真治

    (公財)上原記念生命科学財団 上原記念生命科学財団研究報告集  31   1 - 5 2017.12  [Refereed]

     View Summary

    家族性パーキンソン病の原因遺伝子・アルファシヌクレインは非定型微小管の重要な構成因子であり、細胞質ダイニンが順行性に運搬されるのに必要であることを証明した。

  • Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport

    Toba Shiori, Jin Mingyue, Yamada Masami, Kumamoto Kanako, Matsumoto Sakiko, Yasunaga Takuo, Fukunaga Yuko, Miyazawa Atsuo, Fujita Sakiko, Itoh Kyoko, Fushiki Shinji, Kojima Hiroaki, Wanibuchi Hideki, Arai Yoshiyuki, Nagai Takeharu, Hirotsune Shinji

    SCIENTIFIC REPORTS  7 ( 1 ) 16386 2017.11  [Refereed]

     View Summary

    家族性パーキンソン病の原因遺伝子・アルファシヌクレインは非定型微小管の重要な構成因子であり、細胞質ダイニンが順行性に運搬されるのに必要であることを証明した。

    DOI PubMed

  • Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning

    Kumamoto Kanako, Iguchi Tokuichi, Ishida Ryuichi, Uemura Takuya, Sato Makoto, Hirotsune Shinji

    BIOLOGY OPEN  6 ( 7 ) 1041 - 1055 2017.07  [Refereed]

     View Summary

    滑脳症の原因遺伝子・LIS1は神経細胞の再生に必須であることを証明した。

    DOI PubMed

  • Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics

    Jin Mingyue, Pomp Oz, Shinoda Tomoyasu, Toba Shiori, Torisawa Takayuki, Furuta Ken'ya, Oiwa Kazuhiro, Yasunaga Takuo, Kitagawa Daiju, Matsumura Shigeru, Miyata Takaki, Tan Thong Teck, Reversade Bruno, Hirotsune Shinji

    SCIENTIFIC REPORTS  7   39902 2017.01  [Refereed]

     View Summary

    滑脳症-小脳症の原因遺伝子・カタニンP80はNuMAとともに微小管ネットワークを制御することを証明した。

    DOI PubMed

  • Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway

    Inaba Hironori, Goto Hidemasa, Kasahara Kousuke, Kumamoto Kanako, Yonemura Shigenobu, Inoko Akihito, Yamano Shotaro, Wanibuchi Hideki, He Dongwei, Goshima Naoki, Kiyono Tohru, Hirotsune Shinji, Inagaki Masaki

    JOURNAL OF CELL BIOLOGY  212 ( 4 ) 409 - 423 2016.02  [Refereed]

     View Summary

    Ndel1は繊毛の形成に重要な役割を果たしていることを証明した。

    DOI PubMed

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Review Papers (Misc) 【 display / non-display

Conference Activities & Talks 【 display / non-display

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Charge of on-campus class subject 【 display / non-display

  • Basic Course of Molecular Medicine

    (2019) Graduate school, Special course

  • Cell Biology

    (2019) University, Special course

  • Biochemistry

    (2019) University, Special course

  • Molecular Medicine

    (2019) Graduate school, Special course

  • Practice of biochemistry

    (2019) Graduate school, Special course

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Other educational activity and Special note 【 display / non-display

  • Contribution to FD activities

    (2010)