TERAKITA Akihisa

写真a

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Title

Professor

Laboratory location

Sugimoto Campus

Research Areas 【 display / non-display

Molecular physiology, Animal physiological chemistry, Biophysics, Photobiology

Research Career 【 display / non-display

  • Optogenetic potentials of diverse animal opsins

    (International Collaboration) Project Year :

    2013.04
    -
    Today

    Keyword in research subject:  animal rhodopsins, optogenetics, G protein coupled receptors

  • Molecular physiological study on non-visual photoreception

    (Collaboration in Organization) Project Year :

    1996.04
    -
    Today

    Keyword in research subject:  Non-visual photoreception, opsins, pineal organs, brain photoreception

  • Diversity of rhodopsins and their functions

    (International Collaboration) Project Year :

    1992.04
    -
    Today

    Keyword in research subject:  Photoreception, rhodopsins, phototransduction

  • Molecular mechanism of functional expression of G protein coupled receptor with rhodopsin as a GPCR model.

    (Individual) Project Year :

    1996.04
    -
    2006.03

    Keyword in research subject:  rhodopsin, G protein coupled receptor

Association Memberships 【 display / non-display

  • The Zoologocal Society of Japan

  • THE JAPANESE SOCIETY FOR COMPARATIVE PHYSIOLOGY AND BIOCHEMISTRY

  • The Biophysical Society of Japan

  • Society of Evolutionary Studies, Japan

  • Photobiology association of Japan

Committee Memberships 【 display / non-display

  • 2014.01
    -
    2016.02

    The Biophysical Society of JAPAN  

  • 2011.01
    -
    2013.09

    The Zoologocal Society of Japan  

  • 2010
    -
    2011

    The Biophysical Society of Japan  

  • 2005
    -
    2006

    The Zoologocal Society of Japan  

  • 2004
    -
    Today

    THE JAPANESE SOCIETY FOR COMPARATIVE PHYSIOLOGY AND BIOCHEMISTRY  

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Current Career 【 display / non-display

  • Osaka City University   Graduate School of Science   Biology and Geosciences Course   Professor  

Career 【 display / non-display

  • 2006
     
     

    Osaka City University  

Graduate School 【 display / non-display

  •  
    -
    1989

    Osaka University  Graduate School, Division of Natural Science  physiology 

Graduating School 【 display / non-display

  •  
    -
    1980

    Osaka University   Faculty of Science  

 

Published Papers 【 display / non-display

  • Color opponency with a single kind of bistable opsin in the zebrafish pineal organ

    Wada Seiji, Shen Baoguo, Kawano-Yamashita Emi, Nagata Takashi, Hibi Masahiko, Tamotsu Satoshi, Koyanagi Mitsumasa, Terakita Akihisa

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  115 ( 44 ) 11310 - 11315 2018.10  [Refereed]

    DOI PubMed

  • Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish

    Gerrard Elliot, Mutt Eshita, Nagata Takashi, Koyanagi Mitsumasa, Flock Tilman, Lesca Elena, Schertler Gebhard F. X., Terakita Akihisa, Deupi Xavier, Lucas Robert J.

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  115 ( 24 ) 6201 - 6206 2018.06  [Refereed]

    DOI PubMed

  • Homologs of vertebrate Opn3 potentially serve as a light sensor in nonphotoreceptive tissue

    Koyanagi Mitsumasa, Takada Eiichiro, Nagata Takashi, Tsukamoto Hisao, Terakita Akihisa

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  110 ( 13 ) 4998 - 5003 2013.03  [Refereed]

    DOI PubMed

  • Depth Perception from Image Defocus in a Jumping Spider

    Nagata Takashi, Koyanagi Mitsumasa, Tsukamoto Hisao, Saeki Shinjiro, Isono Kunio, Shichida Yoshinori, Tokunaga Fumio, Kinoshita Michiyo, Arikawa Kentaro, Terakita Akihisa

    SCIENCE  335 ( 6067 ) 469 - 471 2012.01  [Refereed]

    DOI PubMed

  • Beta-arrestin functionally regulates the non-bleaching pigment parapinopsin in lamprey pineal.

    E. Kawano-Yamashita, M.Koyanagi, Y.Shichida, T.Oishi, S. Tamotsu, A.Terakita

    PLoS One  6   e16402 2011  [Refereed]

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Books etc 【 display / non-display

  • Optogenetic Potentials of Diverse Animal Opsins

    Terakita A, Nagata T, Sugihara T and Koyanagi M (Part: Single Work )

    Optogenetics  2015

  • The evolution and diversity of pineal and parapineal photopigments. In “Evolution of Visual and Non-visual Pigments” ed

    Kawano-Yamashita E, Koyanagi M, Wada S and Terakita A (Part: Single Work )

    Springer Series in Vision Research  2014

  • Squid photoreceptor phospholipase C is stimulated by membrane Gqα but not by soluble Gqα.

    (Part: Joint Work )

    FEBS Lett.  1995

Review Papers (Misc) 【 display / non-display

  • Diversity and evolution of animal rhodopsin and phototransduction cascade.

    A. Terakita

    Nova Science Publishers, Inc., New York, Photobiology: Principles, Applications and Effects    179 - 193 2010

  • Diversity and functional properties of bistable pigments.

    Photochem Photobiol Sci.  9   1435 - 1443 2010

  • Gq-coupled rhodopsin subfamily composed of invertebrate visual pigment and melanopsin.

    M. Koyanagi and A. Terakita

    Photochem. Photobiol.  84   1024 - 1030 2008

  • Insight into rhodopsin diversity from viewpoint of counterion

    Terakita A

    J Photosci.  9   33 - 36 2002  [Refereed]  [Invited]

  • The invertebrate phototransduction cascade is similar to that of mammalian hormonal receptor system

    Terakita A, Suzuki T and Tsukahara Y

    RIKEN Review  11   61 - 62 1995  [Refereed]  [Invited]

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Conference Activities & Talks 【 display / non-display

  • Contribution of parapinopsin molecular property to cellular light responses in the zebrafish pineal organ

    Baoguo Shen, Seiji Wada, Emi Kawano-Yamashita, Mitsumasa Koyanagi, Akihisa Terakita

    10th OCARINA International Symposium  2019.03 

  • Animal opsins: non-visual functions and optogenetic applications

    Akihisa Terakita

    10th OCARINA International Symposium  2019.03 

  • Behavioral investigation of non-visual photoreception with pineal-specific opsin- knockout zebrafish

    Genki Nakata, Seiji Wada, Mitsumasa Koyanagi and Akihisa Terakita

    10th OCARINA International Symposium  2019.03 

  • Evaluation of the pineal wavelength discrimination based on a pineal-specific opsin parapinopsin in the zebrafish behaviours

    Tomoka Saito, Seiji wada, Baoguo Shen, Takashi Nagata, Mitsumasa Koyanagi and Akihisa Terakita

    10th OCARINA International Symposium  2019.03 

  • A nobel type of opsin with optogenetic potential: animal opsin-based photopigment as a potential dark-active and light-Inactivated G protein-coupled receptor

    Takashi Nagata, Mitsumasa Koyanagi, Robert Lucas, Akihisa Terakita

    10th OCARINA International Symposium  2019.03 

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Grant-in-Aid for Scientific Research 【 display / non-display

  • Study on a non-visual photoreception lost in the course of mammalian evolution

    Project/Area Number : 15K14568  Grant-in-Aid for challenging Exploratory Research Representative

    Project Year :

    2015.04
    -
    2017.03
     

    Partaker : TERAKITA Akihisa

     View Summary

    We discovered a photoreceptor gene (opsin), which does not exist in eutherian genomes, in marsupial genomes. In this study, we carried out functional analyses of the marsupial opsin spectroscopically and biochemically to understand the diversity of photoreception in mammals. We found that the marsupial opsin indeed forms a photosensitive pigment. In addition, histochemical analysis revealed that the marsupial opsin exhibits a different expression pattern from other opsins in opossum, suggesting a novel photoreception in mammals.

  • Optogenetic application by using diverse rhodopsins of animals

    Project/Area Number : 25650117  Grant-in-Aid for challenging Exploratory Research Representative

    Project Year :

    2013.04
    -
    2015.03
     

     View Summary

    Optogenetics is a technology that can control neural activity by light. Optogenetic potentials of three kinds of animal rhodopsins having the photoregeneration ability were investigated in the cultured cells. The results indicated that the rhodopsins having the photoregeneration ability were suitable for optogenetic tools. In addition, we found that mosquito Opn3 bound to 13-cis-retinal, which is ubiquitously present in animal bodies. The experimental data showed that the 13-cis-retinal binding ability and photoregeneration ability contributed to optogenetic application of mosquito Opn3.

  • Molecular physiological study on functional diversity of non-visual rhodopsins by using isolated cells

    Project/Area Number : 23247011  Grant-in-Aid for Scientific Research(A) Representative

    Project Year :

    2011.04
    -
    2015.03
     

    Partaker : KOYANAGI Mitsumasa

     View Summary

    Functional properties of diverse rhodopsins were investigated. We found that melanopsins in the zebrafish and lamprey horizontal cells had an ability to elevate intracellular calcium concentration upon light absorption. We also found that melanopsin-expressing horizontal cells connected to visual cells containing rhodopsin, which is basically involved in twilight vision, in the lamprey. In the jumping spider, absorption characteristics of a visual pigment, which is phylogenetically close to melanopsins, contributes to depth perception. In addition, homologs of vertebrate encephalopsins had an ability to decrease intracellular cAMP level via Gi type G protein activation.

  • Analysis of photoreceptive ability in mouse brain based on functionally unknown rhodopsin-related proteins

    Project/Area Number : 22657022  Grant-in-Aid for challenging Exploratory Research Representative

    Project Year :

    2010
    -
    2011
     

     View Summary

    It was reported that mRNA of an opsin, encephalopsin has been identified in brain of mammalian and non-mammalian vertebrates and therefore it is of interest to elucidate whether it actually serves as a light-sensor. In vitro experiments suggested that a member of encephalopsin group could act as a light-sensing G protein-coupled receptor. We successfully prepared transgenic mice that express green fluorescence protein(GFP) under regulation of upstream of encephalopsin gene and found GFP expression in the brain cells. The mice could facilitate to specifically isolate encephalopsin-expressing cells and characterize its photosensitivity.

  • Molecular Mechanism of re-isomerization ofretinal in visual cycle

    Project/Area Number : 21570174  Grant-in-Aid for Scientific Research(C) Representative

    Project Year :

    2009
    -
    2011
     

    Partaker : TERAKITA Akihisa, KUSAKABE Takehiro

     View Summary

    Absorption of a photon by visual pigments induces isomerization of 11-cis-retinaldehyde(RAL) chromophore to all-trans-RAL. Here we comparevisual retinoid cycles between different photoreceptors of vertebrates as well as invertebrates. The visual cycle systems in ascidians, the closest living relatives of vertebrates, show an intermediate state between vertebrates and non-chordate invertebrates. The ascidian larva may use retinochrome-like opsin as the major isomerase retinal but RPE65 in asidinan did not isomerase retinal. These results are very interesting in the evolutional standpoints.

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Other external funds procured 【 display / non-display

  • Adapting metazoan opsins for optogenetic applications

    System name: (Commissioned Research)  Partaker / Other

    Project Year :

    2014.12
    -
    2017.11

 

Foreigner acceptance 【 display / non-display

  • Academic year : 2018

     View Details

    Number of foreigners accepted
    1
    Number of International Students
    1

    United Kingdom

  • Academic year : 2017

     View Details

    Number of foreigners accepted
    1
    Number of International Students
    1

    Germany