WANIBUCHI Hideki

写真a

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Title

Professor

Laboratory location

Abeno Campus

Degree 【 display / non-display

  •  -  Doctor of Medicine

Research Areas 【 display / non-display

Environmental impact assessment, Experimental pathology

Research Career 【 display / non-display

  • Carcinogenesis of arsenic

    (Collaboration in Japan)

    Keyword in research subject:  arsenic, dimethylarsinic acid, carcinogenesis

  • Risk assessment of carcinogenesis in environmental chemical

    (International Collaboration)

    Keyword in research subject:  carcinogenesis, risk assessment, environmental chemical

  • Cancer Chemoprevention

    (Collaboration in Japan)

    Keyword in research subject:  chemoprevention, cancer prevention

  • Tumor angiogenesis

    (Collaboration in Organization)

    Keyword in research subject:  angiogenesis, animal experiment

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Medicine   Basic Medicine Course   Professor  

  • Osaka City University   Graduate School of Medicine   Professor  

  • Osaka City University   Graduate School of Medicine   Professor  

  • Osaka City University   Graduate School of Medicine  

  • Osaka City University   Graduate School of Medicine  

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Career 【 display / non-display

  • 2006
     
     

    Osaka City University  

  • 2001
     
     

    Osaka City University  

  • 1993
     
     

    Osaka City University  

  • 1989
     
     

    Osaka City University  

Graduate School 【 display / non-display

  •  
    -
    1989

    Osaka City University  Graduate School, Division of Medicine 

Graduating School 【 display / non-display

  •  
    -
    1984

    Osaka City University   Faculty of Medicine  

 

Published Papers 【 display / non-display

  • Tertiary lymphoid structures show infiltration of effective tumor-resident T cells in gastric cancer.

    Mori T, Tanaka H, Suzuki S, Deguchi S, Yamakoshi Y, Yoshii M, Miki Y, Tamura T, Toyokawa T, Lee S, Muguruma K, Wanibuchi H, Ohira M

    Cancer science  2021.03  [Refereed]

    DOI PubMed

  • Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin.

    Suzuki S, Cohen SM, Arnold LL, Pennington KL, Gi M, Kato H, Naiki T, Naiki-Ito A, Wanibuchi H, Takahashi S

    Toxicology letters  336   32 - 38 2021.01  [Refereed]

    DOI PubMed

  • Accumulation of 8-hydroxydeoxyguanosine, L-arginine and Glucose Metabolites by Liver Tumor Cells Are the Important Characteristic Features of Metabolic Syndrome and Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis.

    Kakehashi A, Suzuki S, Ishii N, Okuno T, Kuwae Y, Fujioka M, Gi M, Stefanov V, Wanibuchi H

    International journal of molecular sciences  21 ( 20 )  2020.10  [Refereed]

    DOI PubMed

  • Role of γ-H2AX as a biomarker for detection of bladder carcinogens in F344 rats.

    Suzuki S, Gi M, Toyoda T, Kato H, Naiki-Ito A, Kakehashi A, Ogawa K, Takahashi S, Wanibuchi H

    Journal of toxicologic pathology  33 ( 4 ) 279 - 285 2020.10  [Refereed]

    DOI PubMed

  • Myeloid-derived suppressor cells are essential partners for immune checkpoint inhibitors in the treatment of cisplatin-resistant bladder cancer.

    Takeyama Y, Kato M, Tamada S, Azuma Y, Shimizu Y, Iguchi T, Yamasaki T, Gi M, Wanibuchi H, Nakatani T

    Cancer letters  479   89 - 99 2020.06  [Refereed]

    DOI PubMed

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Books etc 【 display / non-display

  • Characteristics of diabetes cardiac and renal complications in the OLETF rat.

    Obesity and niddm. -Lessons from the oletf rat.  1999

  • Development of medium-term bioassays for detection of chemopreventive agents In : Food Factors for Cancer Prevention

    Springer  1997

Review Papers (Misc) 【 display / non-display

  • 【泌尿器系疾患と慢性炎症】 ビルハルツ住血吸虫症と膀胱癌

    鰐渕 英機, 魏 民, 行松 直

    (株)北隆館 別冊Bio Clinica: 慢性炎症と疾患  7 ( 4 ) 49 - 53 2018.12  [Refereed]  [Invited]

     View Summary

    ビルハルツ住血吸虫症は、主に泌尿生殖器に感染する寄生虫疾患でありアフリカのほぼ全域、中南東、インドの西部、マダガスカル島などに分布する。ビルハルツ住血吸虫症は膀胱癌の発症と強く関連しており、膀胱癌発症までの潜伏期間は約30年で、その大部分が扁平上皮癌であり、膀胱癌発見時にその多くが浸潤性膀胱癌であることが特徴である。ビルハルツ住血吸虫感染における慢性炎症による酸化的ストレスがDNA傷害を引き起こし、がん関連遺伝子の発現異常、細胞増殖、前癌病変、癌化へと連続することが考えられる。(著者抄録)

  • Prevention of urinary bladder cancer: The interface between experimental and human studies.

    Asian Pacific J. Cancer Prev.  1   15 - 33 2000

  • Case Report ; Molecular cytogenetic identification of cyclin D1 gene amplification in a renal pelvic tumor attributed to phenacetin abuse.

    Pathology International  49   648 - 652 1999

  • Promotion by sodium L-ascorbate in rat two-stage urinary bladder carcinogenesis is dependent on the interval of administration.

    Jpn. J. Cancer Res.  90   16 - 22 1999

  • Lack of inhibitory effects of the Ju-myo protein on development of glautathione S-transferase placental form-positive foci in the male F344 rat liver.

    J. Toxicol. Sci.  24   27 - 31 1999

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Conference Activities & Talks 【 display / non-display

  • Japanese Society of Toxicologic Pathology: Current Status and Future Prospects.

    Hideki Wanibchi.  [Invited]

    第3回中国薬学会毒性病理専門学術検討会  (中華人民共和国)  2019.11 

  • Novel inVivo Bioassays for Prediction of Chemical Carcinogenicity.

    Min Wei  [Invited]

    第3回中国薬学会毒性病理専門学術検討会  (中華人民共和国)  2019.11 

  • ジフェニルアルシン酸の胎仔期ばく露におけるマウス肝発がん性の検討

    魏民、藤岡正喜、大石裕司、鈴木周五、梯アンナ、山口貴嗣、鰐渕英機

    第78回日本癌学会学術総会  (国立京都国際会館(京都市))  2019.09 

  • ラット尿路上皮に対するコチニンの腫瘍促進効果

    鈴木周五、加藤寛之、内木綾、山下依子、鰐渕英機、髙橋智

    第78回日本癌学会学術総会  (国立京都国際会館(京都市))  2019.09 

  • ヒ素毒性・発がん性の最新の展開

    鰐渕 英機

    Biomedical Research on Trace Elements  2018.06  日本微量元素学会

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Grant-in-Aid for Scientific Research 【 display / non-display

  • Study of mechanism of carcinogenesis by 1,2-dichloropropane using animal experiment model

    Project/Area Number : 26340042  Grant-in-Aid for Scientific Research(C) Representative

    Project Year :

    2014.04
    -
    2017.03
     

     View Summary

    In this study, 1,2-dichloropropane (1,2-DCP) and toxicity were investigated using an animal experiment model. As a result, bile duct carcinogenicity was not observed in mouse, rat and hamster in animal test with single exposure of 1,2-DCP and DCM. However, co-exposures of 1,2-DCP and DCM revealed a stronger liver carcinogenic potential compared to single exposure to 1,2-DCP. In addition, it was suggested that as a mechanism of tumor development, a variety of signaling pathways are activated by increased expression of cell proliferation-related factors.

  • Pinpoint targeting of hepatocellular carcinoma for new therapeutic application

    Project/Area Number : 24501354  Grant-in-Aid for Scientific Research(C) Partaker / Other

    Project Year :

    2012.04
    -
    2015.03
     

    Partaker : WANIBUCHI Hideki

     View Summary

    Knockdown (kn) of CNPY2 and CACHD1 in hepatocellular cancer cell lines was found to suppress their cell survival, proliferation and invasion activity. Inactivation of Nrf2, CEBPA, HNF1A and FOXA2 in CNPY2kn and CACHD1kn cells, and c-myc and N-myc in CACHD1kn cells was predicted. CNPY2 and CACHD1 knock-in of COS1 and COS7 cells elevated their cell proliferation and invasion activities likely to be due to activation of TGFbeta signaling. Systemic CNPY2 and CACHD1 knockdown in hepatocellular cancer xenografts nude mice models significantly suppressed the growth of tumors due to inhibition of cell proliferation and induction of tumor cellular apoptosis. These findings demonstrate that CNPY2 and CACHD1 knockdown can inhibit the growth of liver cancer xenografts. CNPY2 and CACHD1 might have a potential as new molecular therapeutic targets for human liver cancer.

  • Proteomics of Human Pancreatic Ductal Adenocarcinoma using FFPE Sections

    Project/Area Number : 23590408  Grant-in-Aid for Scientific Research(C) Partaker / Other

    Project Year :

    2011
    -
    2013
     

    Partaker : KAKEHASHI Anna, WAKASA Kennichi, WANIBUCHI Hideki

     View Summary

    The present study aimed to identify novel useful clinical biomarker at early stages and to elucidate the molecular background of carcinogenesis in human pancreatic ductal adenocarcinomas (PDACs). Proteomes of dissected PDACs and adjacent non-tumor pancreatic tissues from formalin-fixed and paraffin-embedded sections from 10 patients were analyzed using QSTAR Elite LC-MS/MS, ProteinPilot and Ingenuity Pathway Analysis (IPA). Expression of potential biomarker candidates was validated immunohistochemically in 50 PDAC patients, following by survival analyses and statistical comparison of protein expression with clinicopathological variables.
    Paraneoplastic Ma antigen-like 1 (PNMAL1) was selected as a potential biomarker. Immunohistochemical evaluation in 50 PDAC patients revealed that its positive expression was significantly associated with the better overall survival (log-rank test; p=0.009). thus, PNMAL1 is suggested as a novel potential clinically useful prognostic biomarker of PDAC.

  • The strategic proteome analysis for the development of early diagnosis and therapeutic target of primary lung adenocarcinoma

    Project/Area Number : 22591573  Grant-in-Aid for Scientific Research(C) Partaker / Other

    Project Year :

    2010
    -
    2012
     

    Partaker : KAKEHASHI Anna, WANIBUCHI Hideki

     View Summary

    The comprehensive proteome analysis with frozen sample of lung adenocarcinoma tissue and adjacent normal tissue identified anterior gradient protein 2 homolog (AGR2) as a candidate protein for potential biomarker. Immunohistochemical staining showed that

  • Integrated cancer research using in vivo models

    Project/Area Number : 17012017  Grant-in-Aid for Scientific Research on Priority Areas Partaker / Other

    Project Year :

    2005
    -
    2009
     

    Partaker : YAMADA Gen, ARAKI Kimi, ITOH Toshio, KATOH Hideki, NAKAGATA Naomi, NAKO Kazuki, OBATA Yuichi, YAMAZAKI Yukiko, MATSUI Yasuhisa, WANIBUCHI Hideki, FUKAMACHI Hiroshi, MITSUMORI Kunitoshi, USHIJIMA Toshikazu, OGAWA Katsuhiro, TATEMATSU Masae

     View Summary

    We organized 7 groups to support cancer research in Japan during 2005 and 2009 academic year. We produced 1463 transgenic or knockout mouse strains and responded to 191 consultations by distributing materials such as targeting vectors. The number of request for conditional gene targeting instead of simple knockout is increasing in recent years. Microbiological monitoring and genetic monitoring using biochemical/microsattelite markers were accomplished for 25,769 samples in 1798 cases and 1,367 samples, respectively. Due to these efforts, infection to laboratory mouse is rarely seen under SPF condition in these years. We cryopreserved embryos and sperms for 7,985 strains and supplied 4,358 strains. Infected 2739 strains were recovered and cleaned from viruses using in vitro fertilization technique. We started to supply embryos under refrigerated condition using a new method by which recovered embryo can be preserved for 3 or 4 days. We held the course for reproductive engineering for 24 times to 136 trainees. CARD-RBASE was established with necessary function such as links to other web sites. We supplied 7,357 cell lines for cancer researchers. We also carried out pathologic analyses for 55 genetically engineered mouse strains upon request.

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Charge of on-campus class subject 【 display / non-display

  • Pathologic Basis of Disease

    (2020) University, Special course

  • Pathologic Basis of Disease

    (2019) University, Special course

  • Pathologic Basis of Disease

    (2018) University, Special course

Other educational activity and Special note 【 display / non-display

  • Contribution to internationalization

    (2020)

  • Extra-Curricular Activities

    (2020)

Educational activity record 【 display / non-display

  • Academic year : 2020

     View Details

    Number of instructed the graduation thesis
    0
    Number of graduation thesis reviews
    0
    Number of instructed the Master course
    1
    Number of instructed the Doctoral course
    1
    Number of master's thesis reviews (chief)
    0
    Number of master's thesis reviews (vice-chief)
    0
    Number of doctoral thesis reviews (chief)
    0
    Number of doctoral thesis reviews (vice-chief)
    8
  • Academic year : 2019

     View Details

    Number of instructed the graduation thesis
    0
    Number of graduation thesis reviews
    0
    Number of instructed the Master course
    0
    Number of instructed the Doctoral course
    2
    Number of master's thesis reviews (chief)
    0
    Number of master's thesis reviews (vice-chief)
    0
    Number of doctoral thesis reviews (chief)
    1
    Number of doctoral thesis reviews (vice-chief)
    3
  • Academic year : 2018

     View Details

    Number of instructed the graduation thesis
    0
    Number of graduation thesis reviews
    0
    Number of instructed the Master course
    0
    Number of instructed the Doctoral course
    2
    Number of master's thesis reviews (chief)
    0
    Number of master's thesis reviews (vice-chief)
    0
    Number of doctoral thesis reviews (chief)
    1
    Number of doctoral thesis reviews (vice-chief)
    3
  • Academic year : 2017

     View Details

    Number of instructed the graduation thesis
    0
    Number of graduation thesis reviews
    0
    Number of instructed the Master course
    2
    Number of instructed the Doctoral course
    1
    Number of master's thesis reviews (chief)
    1
    Number of master's thesis reviews (vice-chief)
    3
    Number of doctoral thesis reviews (chief)
    2
    Number of doctoral thesis reviews (vice-chief)
    5
 

Theme of Possible Research Exchange 【 display / non-display

  • Cancer chemoprevention

    Research theme : Analize of cancer chemopreventive effect of chemicals in carcinogenesis bioassay using experimental animals.

    Keyword : cancer prevention, anti-cancer drug, animal experiment, transgenic animal, medium-term bioassay of2001 carcinogen

     View Details

    Application fields / methods etc : We analyze the chemopreventive effects of chemicals with the marker of preneoplastic lesions, comparing the control with treatment of chemicals.

    Core knowledge, technology, information etc : medium-term bioassay of carcinogen

 

Foreigner acceptance 【 display / non-display

  • Academic year : 2020

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    Number of foreigners accepted
    0
    Number of International Students
    0
  • Academic year : 2019

     View Details

    Number of International Students
    1
  • Academic year : 2018

     View Details

    Number of foreigners accepted
    1
    Number of International Students
    1

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  • Academic year : 2014

     View Details

    Number of foreigners accepted
    1

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