MORIMOTO Yoshiki

写真a

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Title

Professor

Laboratory location

Sugimoto Campus

Mail Address

E-mail address

Degree 【 display / non-display

  • Hokkaido University -  Doctor of Science

  • Hokkaido University -  Master of Science

Research Areas 【 display / non-display

Organic chemistry, Natural Products Chemistry, Synthetic chemistry, Substance Transformation, Synthetic Organic Chemistry

Research Interests 【 display / non-display

Cascade Reaction, Chemical Biology, Asymmetric Synthesis, Total Synthesis, Natural Product Synthesis, Structure Determination, Structure-Activity Relationships, Biosynthesis, Biomimetic Synthesis, Biological Activity

Research Career 【 display / non-display

Association Memberships 【 display / non-display

  • The Chemical Society of Japan

  • The Society of Synthetic Organic Chemistry, Japan

Committee Memberships 【 display / non-display

  • 2007
    -
    2008

    The Chemical Society of Japan  

  • 2003
    -
    2006

    The Society of Synthetic Organic Chemistry, Japan  

  • 2000
    -
    2003

    The Society of Synthetic Organic Chemistry, Japan  

  • 1997
    -
    1999

    The Chemical Society of Japan  

Awards & Honors 【 display / non-display

  • Nagase Research Promotion Award

    Exploration of Natural Products with Enantiodivergency and Clarification of Their Production Mechanism

    2018.04   Nagase Science Technology Foundation

    Winner : Yoshiki Morimoto

  • Kansai Branch Award in Synthetic Organic Chemistry, Japan

    Development of Stereoselective Polytetrahydrofuran Construction Method and the Application to Natural Product Synthesis

    2003.11   Kansai Branch, The Society of Synthetic Organic Chemistry, Japan

    Winner : Yoshiki Morimoto

  • Lectureship for Young Chemists of 79th National Meeting of the Chemical Society of Japan

    Total Synthesis of Highly Symmetric Squalene-derived Cytotoxic Polyethers Teurilene and Glabrescol

    2001.03   The Chemical Society of Japan

    Winner : Yoshiki Morimoto

  • Fujisawa Pharmaceutical Award in Synthetic Organic Chemistry, Japan

    Development of Oxidation Reactions Using Rhenium at High Oxidation State and the Application to Organic Synthesis

    1999.03   The Society of Synthetic Organic Chemistry, Japan

    Winner : Yoshiki Morimoto

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Science   Molecular Materials Science Course   Professor  

Career 【 display / non-display

  • 2007.04
    -
    Today

    Osaka City University   Graduate School of Science   Professor

  • 2001.04
    -
    2007.03

    Osaka City University   Graduate School of Science   Associate Professor

  • 1999.04
    -
    2001.03

    Osaka City University   School of Science   Associate Professor

  • 1995.10
    -
    1999.03

    Osaka City University   School of Science   Lecturer

  • 1992.04
    -
    1995.09

    Osaka City University   School of Science   Research Associate

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Graduate School 【 display / non-display

  • 1987.04
    -
    1991.03

    Hokkaido University  Graduate School, Division of Natural Science  Division of Chemistry 

Graduating School 【 display / non-display

  • 1981.04
    -
    1985.03

    Hokkaido University   Faculty of Science   Department of Chemistry

 

Published Papers 【 display / non-display

  • Formal Total Synthesis of Histrionicotoxin Alkaloids via Hg(OTf)2-Catalyzed Cycloisomerization and SmI2-Induced Ring Expansion

    Kunihiro Matsumura, Keisuke Nishikawa, Hiroaki Yoshida, Matsumi Doe, and Yoshiki Morimoto

    RSC ADVANCES  8 ( 21 ) 11296 - 11303 2018.03  [Refereed]

    DOI

  • Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages

    Momochika Kumagai, Akio Watanabe, Izumi Yoshida, Takashi Mishima, Munetomo Nakamura, Keisuke Nishikawa, and Yoshiki Morimoto

    BIOLOGICAL & PHARMACEUTICAL BULLETIN  41 ( 1 ) 132 - 137 2018.01  [Refereed]

     View Summary

    Anti-inflammatory activity of aculeatin and toddaculin, which are coumarins with a similar structure isolated from Toddalia asiatica (L.) LAM., was evaluated using lipopolysaccharide (LPS)-stimulated RAW264 mouse macrophage cells. Both aculeatin and toddaculin significantly inhibited mRNA expression of inflammatory mediators and nitric oxide production. Furthermore, Toddaculin suppressed LPS-induced phosphorylation of p38 and extracellular signal-regulated kinase (ERK)1/2 and inhibited LPS-induced activation of nuclear factor-kappaB (NF-κB). However, aculeatin did not exhibit such effects, suggesting that aculeatin and toddaculin suppress LPS-induced inflammation of RAW264 cells via different mechanisms. The cellular uptake of these compounds was also evaluated. Toddaculin was detected in RAW264 cells after 4 and 24 h.
    However, aculeatin levels were not observed in RAW264 cells at all incubation intervals. These results indicate that de-epoxidation of a prenyl group can increase hydrophobicity of molecule and is thought to accelerate
    cellular uptake and/or interactions with the phospholipid bilayers of cell membranes.

  • Total Syntheses of Lepadiformine Marine Alkaloids with Enantiodivergency, Utilizing Hg(OTf)2-Catalyzed Cycloisomerization Reaction and their Cytotoxic Activities

    Keisuke Nishikawa, Kengo Yamauchi, Seiho Kikuchi, Shinnosuke Ezaki, Tomoyuki Koyama, Haruka Nokubo, Kunihiro Matsumura, Takeshi Kodama, Momochika Kumagai, and Yoshiki Morimoto

    CHEMISTRY-A EUROPEAN JOURNAL  23 ( 40 ) 9535 - 9545 2017.07  [Refereed]

    DOI

  • Synthesis of Novel 5,6-Dehydrokawain Analogs as Osteogenic Inducers and Their Action Mechanisms

    Momochika Kumagai, Keisuke Nishikawa, Takashi Mishima, Izumi Yoshida, Masahiro Ide, Keiko Koizumi, Munetomo Nakamura, and Yoshiki Morimoto

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS  27 ( 11 ) 2401 - 2406 2017.06  [Refereed]

    DOI

  • Total Synthesis of the Cytotoxic Marine Triterpenoid Isodehydrothyrsiferol Reveals Partial Enantiodivergency in the Thyrsiferol Family of Natural Products

    Akihiro Hoshino, Haruka Nakai, Miyako Morino, Keisuke Nishikawa, Takeshi Kodama, Kento Nishikibe, and Yoshiki Morimoto

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  56 ( 11 ) 3064 - 3068 2017.03  [Refereed]

    DOI

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Books etc 【 display / non-display

  • Basic Chemistry Experiments, Third Modified Edition

    Ed. Chemistry Experiment Group in Liberal Arts and Sciences, Graduate School of Science, Osaka City University (Part: Joint Work )

    Fukuro Shuppan  2017

  • Basic Chemistry Experiments, Second Modified Edition

    Ed. Chemistry Experiment Group in Liberal Arts and Sciences, Graduate School of Science, Osaka City University (Part: Joint Work )

    Fukuro Shuppan  2014

  • Reactions Culminated in Natural Product Synthesis—Know-how and Points in Experiments

    Ed. The Society of Synthetic Organic Chemistry, Japan (Part: Contributor )

    Kagakudojin Company, Limited  2011

  • Basic Chemistry Experiments, Modified Edition

    Ed. Chemistry Experiment Group in Liberal Arts and Sciences, Graduate School of Science, Osaka City University (Part: Joint Work )

    Fukuro Shuppan  2010

  • High School Students//Chemistry Declaration Part 3

    Hiroshi Nakazawa and Yoshiki Morimoto et al. (Part: Contributor )

    u-time Publishing Company, Limited  2010

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Review Papers (Misc) 【 display / non-display

  • Creation of Molecular Technology towards Development of Pharmaceuticals for Complex Molecules

    Yoshiki Morimoto

    Reports of the 45th Grant-Supported Research from the Astellas Foundation for Research on Metabolic Disorders    https://www.astellas.com/jp/byoutai/other/reports_h25/pdf/25-49_morimoto.pdf 2016

  • Studies on the Biogenetic Key Reaction of Triterpene Polyethers

    Yoshiki Morimoto

    Report of Grant-Supported Research from the Asahi Glass Foundation, 2011  2011

  • What Is University?

    Yoshiki Morimoto

    Rutsubo  58   46 - 48 2010

  • Studies on Chemical Synthesis of Structurally Novel Cytotoxic Alkaloids Haouamines toward Pharmaceuticals

    Yoshiki Morimoto

    Research Papers of the Suzuki Memorial Foundation  27   391 - 395 2010

  • Studies on the Molecular Science of Cytotoxic Oxasqualenoids Based on Chemical Synthesis

    Yoshiki Morimoto

    Research Report on Grant-in-Aid for Scientific Research (C) in 2005–2008    1 - 89 2008

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Conference Activities & Talks 【 display / non-display

  • Toward Efficient Synthesis of Cytotoxic Bromotriterpenoid Middle Molecules Integrated by Chemical and Enzymatic Syntheses

    Yoshiki Morimoto

    The 4th International Symposium on Middle Molecular Strategy  (仙台)  2018.11 

  • Total Synthesis of Histrionicotoxin 235A

    Kunihiro Matsumura, Hiroaki Yoshida, Tomoyuki Koyama, Toshiki Niwa, Keisuke Nishikawa, and Yoshiki Morimoto

    The 14th International Kyoto Conference on New Aspects of Organic Chemistry  (京都)  2018.11 

  • サイヤセノールAの全合成

    西川慶祐,錦部健人,森本善樹

    第38回有機合成若手セミナー「明日の有機合成を担う人のために」  (西宮)  2018.08 

  • ヒストリオニコトキシン235Aの全合成

    松村匡浩,西川慶祐,吉田浩明,高見麻衣,丹羽俊輝,小山智之,森本善樹

    第38回有機合成若手セミナー「明日の有機合成を担う人のために」  (西宮)  2018.08 

  • Tetrodotoxin骨格の合成研究

    野口隆幸,荒木勇介,丸山高広,西川慶祐,森本善樹

    第38回有機合成若手セミナー「明日の有機合成を担う人のために」  (西宮)  2018.08 

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Grant-in-Aid for Scientific Research 【 display / non-display

  • Efficient Synthesis of Triterpenoid Middle Molecules by Integrating Chemical and Enzymatic Syntheses

    Grant-in-Aid for Scientific Research on Innovative Areas Representative

    Project Year :

    2018.04
    -
    2020.03
     

    Partaker : Tatsufumi Okino and Keisuke Nishikawa

  • Chemical Biology of Halogenated Antifouling Compounds

    Grant-in-Aid for Scientific Research(B) Partaker / Other

    Project Year :

    2016.04
    -
    2020.03
     

  • Studies on Molecular Science of Biologically Active Natural Products Based on Chemical Synthesis

    Grant-in-Aid for Scientific Research(B) Representative

    Project Year :

    2008.04
    -
    2012.03
     

  • Molecular Scientific Research on Cytotoxic Oxasqualenoids Based on Chemical Synthesis

    Grant-in-Aid for Scientific Research(C) Representative

    Project Year :

    2005.04
    -
    2008.03
     

  • Structures and Dynamics of Water Clusters Stabilized by Molecular Porous Coordination Space

    Grant-in-Aid for Scientific Research on Priority Areas Partaker / Other

    Project Year :

    2005.04
    -
    2006.03
     

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Other external funds procured 【 display / non-display

  • Exploration of Natural Products with Enantiodivergency and Clarification of Their Production Mechanism

    System name: Research Grant from the Nagase Science Technology Foundation (Research grant)  Representative

    Project Year :

    2018.04
    -
    2019.03

    Tatsufumi Okino and Keisuke Nishikawa

  • Creation of Molecular Technology towards Development of Pharmaceuticals for Complex Molecules

    System name: Research Grant from the Astellas Foundation for Research on Metabolic Disorders (Research grant)  Representative

    Project Year :

    2013
    -
    2014

  • Studies on the Biomimetic Key Reaction of Triterpene Polyethers

    System name: Research Encouragement on Natural Sciences from the Asahi Glass Foundation (Research grant)  Representative

    Project Year :

    2010.04
    -
    2011.03

  • Dynamic Molecular Science Innovation

    System name: Research on Priority Areas from the Osaka City University (University Strategic Research Funds)  Representative

    Project Year :

    2010
    -
    2012.03

  • Studies on Chemical Synthesis of Structurally Novel Cytotoxic Alkaloids Haouamines toward Pharmaceuticals

    System name: Research Grant from the Suzuki Memorial Foundation (Research grant)  Representative

    Project Year :

    2007
    -
    2008

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Other educational activity and Special note 【 display / non-display

  • Contribution to internationalization

    (2018)

  • Extra-Curricular Activities

    (2018)

  • Contribution to University-wide Cross-training program

    (2018)

  • Improvement of educational methods

    (2018)

  • Improvement of educational methods

    (2017)

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Foreigner acceptance 【 display / non-display

  • Academic year : 2018

     View Details

    Number of foreigners accepted
    0
    Number of International Students
    1
  • Academic year : 2017

     View Details

    Number of foreigners accepted
    0
    Number of International Students
    0