EMOTO Masanori


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Laboratory location

Abeno Campus

Degree 【 display / non-display

  • Osaka City University -  Doctor of Medicine

Research Areas 【 display / non-display

Internal Medicine in General, Internal medicine of metabolism and diabetology, Nephrology

Research Career 【 display / non-display

  • Study on Diabetes Mellitus and Obesity

    (Collaboration in Organization)

    Keyword in research subject:  Diabetes Mellitus, Obesity

  • Study on Renal Failure

    (Collaboration in Organization)

    Keyword in research subject:  Renal Failure

Association Memberships 【 display / non-display


  • American Diabetes Association

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Medicine   Clinical Medicine Course   Professor  

  • Osaka City University   University Hospital  

Graduate School 【 display / non-display


    Osaka City University  Graduate School, Division of Medicine 

Graduating School 【 display / non-display


    Osaka City University   Faculty of Medicine  


Published Papers 【 display / non-display

  • Plasma 1,5-anhydroglucitol concentration in patients with end-stage renal disease with and without diabetes

    Nephron  61 ( 2 ) 181 - 186 1992

  • Improvement of glycemic control by treatment for insomnia with suvorexant in type 2 diabetes mellitus

    Toi Norikazu, Inaba Masaaki, Kurajoh Masafumi, Morioka Tomoaki, Hayashi Noriyuki, Hirota Tomoe, Miyaoka Daichi, Emoto Masanori, Yamada Shinsuke



  • Significance of urinary C-megalin excretion in vitamin D metabolism in pre-dialysis CKD patients

    Toi Norikazu, Inaba Masaaki, Ishimura Eiji, Tsugawa Naoko, Imanishi Yasuo, Emoto Masanori, Hirayama Yoshiaki, Nakatani Shinya, Saito Akihiko, Yamada Shinsuke

    SCIENTIFIC REPORTS  9 2019.02  [Refereed]


  • Impaired residual renal function predicts denosumab-induced serum calcium decrement as well as increment of bone mineral density in non-severe renal insufficiency

    Miyaoka D., Imanishi Y., Ohara M., Hayashi N., Nagata Y., Yamada S., Mori K., Emoto M., Inaba M.

    OSTEOPOROSIS INTERNATIONAL  30 ( 1 ) 241 - 249 2019.01  [Refereed]


  • Effect of Oral Alfacalcidol on Clinical Outcomes in Patients Without Secondary Hyperparathyroidism Receiving Maintenance Hemodialysis The J-DAVID Randomized Clinical Trial

    Shoji Tetsuo, Inaba Masaaki, Fukagawa Masafumi, Ando Ryoichi, Emoto Masanori, Fujii Hisako, Fujimori Akira, Fukui Mitsuru, Hase Hiroki, Hashimoto Tetsuya, Hirakata Hideki, Honda Hirokazu, Hosoya Tatsuo, Ikari Yuji, Inaguma Daijo, Inoue Toru, Isaka Yoshitaka, Iseki Kunitoshi, Ishimura Eiji, Itami Noritomo, Ito Chiharu, Kakuta Toshitaka, Kawai Toru, Kawanishi Hideki, Kobayashi Shuzo, Kumagai Junko, Maekawa Kiyoshi, Masakane Ikuto, Minakuchi Jun, Mitsuiki Koji, Mizuguchi Takashi, Morimoto Satoshi, Murohara Toyoaki, Nakatani Tatsuya, Negi Shigeo, Nishi Shinichi, Nishikawa Mitsushige, Ogawa Tetsuya, Ohta Kazumichi, Ohtake Takayasu, Okamura Mikio, Okuno Senji, Shigematsu Takashi, Sugimoto Toshitsugu, Suzuki Masashi, Tahara Hideki, Takemoto Yoshiaki, Tanaka Kenji, Tominaga Yoshihiro, Tsubakihara Yoshiharu, Tsujimoto Yoshihiro, Tsuruya Kazuhiko, Ueda Shinichiro, Watanabe Yuzo, Yamagata Kunihiro, Yamakawa Tomoyuki, Yano Shozo, Yokoyama Keitaro, Yorioka Noriaki, Yoshiyama Minoru, Nishizawa Yoshiki

    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION  320 ( 22 ) 2325 - 2334 2018.12  [Refereed]


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Books etc 【 display / non-display

Review Papers (Misc) 【 display / non-display

  • Increased resistance of retinal blood flow in insulin-dependent diabetic patients without retinopathy

    The 54th Annual meeting & scientific sessions of American Diabetes Association  1994

  • Calcitonin secretion and its regulation.

    The Bone  6 ( 1 ) 33 - 39 1992

Grant-in-Aid for Scientific Research 【 display / non-display

  • Epidemiology of physical fitness and physical activity in hemodialysis patients

    Project/Area Number : 18H03053  Grant-in-Aid for Scientific Research(B) Representative

    Project Year :


  • Clinical evaluation of the hypothesis of CPP as a pathogen in chronic kidney disease

    Project/Area Number : 15K09294  Grant-in-Aid for Scientific Research(C) Representative

    Project Year :


    Partaker : NAKATANI Shinya, UEDONO Hideki

     View Summary

    To evaluate the role of calci-protein particle (CPP) as a pathogen in chronic kidney disease, we measured serum concentration of CPP and T50, the latter being the time for CPP to transform in vitro to more cytotoxic form secondary CPP. Serum concentration of CPP was not increased in hemodialysis patients than healthy volunteers, and no correlation was found between CPP level and T50. In a cohort of hemodialysis patients, a shorter T50 predicted a higher risk of mortality, but CPP did not. These results support the hypothesis that CPP, following transformation in vivo, could play a pathological role in chronic kidney disease.

  • The establishment of clinical implications regarding dual properties of carotid atherosclerosis in metabolic syndrome

    Project/Area Number : 20591068  Grant-in-Aid for Scientific Research(C) Representative

    Project Year :


    Partaker : MORI Katsuhito

     View Summary

    In metabolic syndrome including diabetes mellitus, dyslipidemia, and obesity, the morphological and functional changes of atherosclerosis of carotid artery, intima-media thickness (IMT) and stiffness parameter, were found to be differently associated with classical risk factors, novel biomarkers (fetuin-A and TRAIL), endothelial and smooth muscle dysfunction, and cardiovascular diseases. These findings indicate that simultaneous quantitative measurements of these dual properties of early atherosclerotic changes are of great importance in view of diagnosis, monitoring and treatment for atherosclerotic diseases.

  • Establishment of prediction for the development of atherosclerosis by new methods of clinical insulin resistance indexes

    Project/Area Number : 16615005  Grant-in-Aid for Scientific Research(C) Representative

    Project Year :


    Partaker : SHOJI Tetsuo

     View Summary

    We explored the simple and precise clinical index for evaluating insulin resistance. As a gold standard index, insulin resistance was measured by euglycemic hyperinsulinemic clamp (Clamp IR) using artificial pancreas in 40 healthy, 9 impaired glucose tolerance and 251 type 2 diabetic subjects. We examined the impacts of possible new factors and conventional factors on insulin resistance (clamp IR) by simple and multiple regression analyses. As conventional factors, HOMA-IR, BMI, male, creatinin HDL-cholesterol and free fatty acid levels were independent factors to clamp IR by multiple regression models. Serum adiponectin and fetuin-A levels were found to be weak but significant independent contributors to clamp IR (Diabetes Care 29:468, 2006). We also reported a new index of the combination of HOMA-IR and adiponectin as a clinical insulin resistance index, by a collaboration with other investigators (Diabetes Res Clin Pract, 2007, In press). Furthermore, we investigated the association with these insulin resistance indexes and carotid atherosclerosis, intima medial thickness (IMT) and stiffness parameter evaluated by ultrasound. Serum adiponectin and fetuin-A levels were weakly but significantly associated with stiffness parameter(Metabolism 55:587-592, 2006 ; Clin Endocrinol (Oxf) 66:246-250, 2007). The increase of serum adiponectin level by pioglitazon treatment induced the improvement of stiffness parameter (Metabolism 55:996-1001, 2006). The progression rate (per year) of IMT was weakly associated with clamp IR and HOMA-IR, but that of stiffness parameter was not.

  • Research on the effect of systemic arteriosclerosis and genotypes on intrarenal hemodynamic abnormalities in patients with type 2 diabetes mellitus

    Project/Area Number : 10671001  Grant-in-Aid for Scientific Research(C) Representative

    Project Year :


    Partaker : EMOTO Masanori, KAWAGISHI Takahiko, NISHIZAWA Yoshiki, INABA Masaaki, MATSUMOTO Naoki

     View Summary

    In order to explore the effect of arteriosclerosis and genetic factor on intrarenal hemodynamic abnormalities in patlents with 2 diabetes mellitus (DM), restive index (RI values) of interlobar artery of the kidney was measured with use of duplex Doppler sonography. 1. Relationship between glomerular filtration rate (GFR) and arteriosclerosis (systemic and intrarenal). In 61 DM patients, GFR's, parameters of systemic arteriosclerosis (IMT and stiffness- β of the carotid arteries) and RI values were measured. Multiple regression analysis showed that GFR were significantly affected by IMT, stiffness-β, and RI values, thus showing GFR are affected by systemic and intrarenal arteriosclerosis. (Taniwaki H, et al. Diabetes Care 21 : 1848-1855, 1988). 2. Effect of genotype of angiotensin converting enzyme (ACE) and nitric oxide synthase (ecNOS) on intrarenal hemodynamics. 123 DM patients were enrolled. Frequency of each genotype of ACE (II, ID or DD) and ecNOS (4a allele + or -) is not significantly different in various stage of diabetic nephropathy. RI values were significantly affected by age and duration of DM, but not by ACE or ecNOS genotypes. The results suggest intrarenal hemodynamics were affected largely by arteriosclerosis. (Taniwaki H, et al. in submission). 3. Intrarenal hemodynamic abnormalities in chronic renal failure (CRF) patients. 48 DM-CRF and 42 nonDM-CRF patients were enrolled. RI values in DM-CRF patients were significantly higher than those of nonDM-CRF. Multiple regression analysis showed that RI values were significantly affected by the presence of DM, age, and serum creatinine (RィイD12ィエD1=0.563, p<0.0001), suggesting advanced renal arteriosclerosis in DM-CRF patients (Matsumoto N, et al. Nephron, in press). 4. Effect of vasodilating agents on intrarenal hemodvnamics 118 DM patients were enrolled. Both before and after nitroglycerine (NTG) 0.3 mg administration, RI values were measured. Compared to control subjects, decrease in RI values by NTG is significantly lower in DM. Particularly, DM patients with smoking or with advanced nephropathy stage had a significantly less responsiveness to NTG (Matsumoto et al, Diabetic Nephropathy, in press). Furthermore, changes in RI values after intravenous administration of arginine were significantly less in DM patients, suggesting impairment of endothelial cell dependent vasodilation in DM patients (Kawagishi T, et al. Arterioscler Thromb Vas Biol 19 : 2509-2516, 1999).


Theme of Possible Research Exchange 【 display / non-display

  • Clinical study on insulin resistance in diabetes

    Type of research exchange : Technical consultation

    Keyword : Insulin resistance, Diabetes mellitus, Clinical study

     View Details

    Core knowledge, technology, information etc : Glucose clamp technique using artificial pancreas

  • Clinical study on ealry lesions of atherosclerosis in diabetes

    Type of research exchange : Technical consultation

    Keyword : Intimal-medial thickness, IMT, Stiffness, Diabetes mellitus, Ultrasonography

     View Details

    Core knowledge, technology, information etc : Quantitative evaluation of early atherosclerosis by ultrasonography