NAGASAKI Takeshi

写真a

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Title

Professor

Laboratory location

Sugimoto Campus

Mail Address

E-mail address

Degree 【 display / non-display

  • Kyushu University -  Doctor of Engineering

Research Areas 【 display / non-display

Medical Bioengineering, Biofunctional Engineering

Research Interests 【 display / non-display

Drug Delivery System, Neutron Capture Therapy, Anti-cancer agent, Cell Scaffold, Tissue Adhesive

Research Career 【 display / non-display

  • Boron Delivery System for Boron Neutron Capture Therapy

    (Collaboration in Japan) Project Year :

    2010.04
    -
    Today

  • Hydrogel as Hemostat

    (Collaboration in Japan) Project Year :

    2006.04
    -
    Today

    Keyword in research subject:  Hemostat, Hydro Gel

  • Controlled Drug Delivery by Using Functional Protein

    (Collaboration in Organization) Project Year :

    2000.04
    -
    Today

    Keyword in research subject:  drug delivery, intracellular trafficking, functional protein

  • Development of Cell Culutre Devices

    (Collaboration in Japan) Project Year :

    2003.04
    -
    Today

    Keyword in research subject:  cell culture, polycation, cell adhesion

  • Biopolymer-based gene carrier

    (Collaboration in Japan) Project Year :

    1999.04
    -
    Today

    Keyword in research subject:  gene carrier, biopolymer, polycation

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Committee Memberships 【 display / non-display

  • 2021.07
    -
    Today

    Japanese Society of Neutron Capture Therapy   Executive Board Member

  • 2008
    -
    Today

    Association of Research for Host-Guest and Supramolecular Chemistry   Board

  • 2000
    -
    Today

    The Japanese Society of Gene Design and Delivery   Board

Awards & Honors 【 display / non-display

  • Bull. Chem. Soc. Jpn. Award

    2007  

  • HGCS Japan Award of Excellence 2006

    2006  

  • Bull. Chem. Soc. Jpn. Award

    2004  

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Engineering   Applied Chemistry and Bioengineering Course   Professor  

  • Osaka City University   Graduate School of Engineering   Dean  

Career 【 display / non-display

  • 2007.04
     
     

    Osaka City University  

  • 1995.04
     
     

    Osaka City University  

  • 1994.04
     
     

    Osaka City University  

  • 1991
    -
    1994

    Faculty of Engineering, Kyushu University   Research Associate

Graduate School 【 display / non-display

  • 1988.04
    -
    1991.03

    Kyushu University  Graduate School, Division of Engineering  Department of Organic Synthesis 

  • 1986.04
    -
    1988.03

    Tokyo University of Agriculture and Technology  Graduate School, Division of Engineering  Department of Applied Chemistry for Resources 

Graduating School 【 display / non-display

  • 1982.04
    -
    1986.03

    Tokyo University of Agriculture and Technology   Faculty of Engineering   Department of Applied Chemistry for Resources

 

Published Papers 【 display / non-display

  • A new "Mitsunobu homocoupling" reaction using aldol adducts of kojic acid

    Azuma Hideki, Morishima Yasuhito, Nakaguro Keijin, Kato Reiko, Nagasaki Takeshi

    TETRAHEDRON  94 2021.08  [Refereed]

    DOI

  • Tumor-targeting hyaluronic acid/fluorescent carborane complex for boron neutron capture therapy

    Yamana Keita, Kawasaki Riku, Sanada Yu, Tabata Anri, Bando Kaori, Yoshikawa Kouhei, Azuma Hideki, Sakurai Yoshinori, Masunaga Shin-ichiro, Suzuki Minoru, Sugikawa Kouta, Nagasaki Takeshi, Ikeda Atsushi

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  559   210 - 216 2021.06  [Refereed]

    DOI PubMed

  • Mechanism toward Turn-on of Polysaccharide-Porphyrin Complexes for Fluorescence Probes and Photosensitizers in Photodynamic Therapy in Living Cells

    Hino Shodai, Funada Rikushi, Sugikawa Kouta, Kawasaki Riku, Koumoto Kazuya, Suzuki Toshio, Nagasaki Takeshi, Ikeda Atsushi

    CHEMMEDCHEM  16 ( 5 ) 793 - 803 2021.03  [Refereed]

    DOI PubMed

  • Tumor Growth Suppression With Novel Intra-arterial Chemotherapy Using Epirubicin-entrapped Water-in-oil-in-water Emulsion In Vivo

    Hironobu Yanagie, Takashi Fujino , Masashi Yanagawa, Toshimitsu Terao, Takashi Imagawa, Mitsuteru Fujihara, Yasuyuki Morishita, Ryouji Mizumachi, Yuuji Murata, Novriana Dewi, Yuuya Ono, Ichiro Ikushima, Koji Seguchi, Masashi Nagata, Yasumasa Nonaka, Yoshitaka Furuya, Tomoyuki Hisa, Takeshi Nagasaki, Kazuhiko Arimori, Tadao Nakashima, Takumichi Sugihara, Kazuhiro Kakimi, Minoru Ono, Jun Nakajima, Masazumi Eriguchi, Shushi Higashi, Hiroyuki Takahashi

    In Vivo  35 ( 1 ) 239 - 248 2021.02  [Refereed]

  • Cancer-Targeting Hyaluronic Acid/Carboranyl Pyrene Complex for Boron Neutron Capture Therapy

    K. Yamana, R. Kawasaki, Y. Sanada, S. Masunaga, M. Suzuki, Y. Sakurai, A. Tabata, K. Bando, K. Yoshi-kawa, K. Sugikawa, T. Nagasaki, and A. Ikeda

    KURNS Progress Report 2020  2021  [Refereed]

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Books etc 【 display / non-display

  • Ultrasound-mediated Transfection with Liposomal Bubbles Delivers Plasmid DNA Directly into Nucleu

    Takeshi Kawazu, Kazumi Hakamada, Yusuke Oda, Jun Miyake, Kazuo Maruyama, and Takeshi Nagasaki (Part: Joint Work )

    Chem. Lett.  2011.03

  • Bottom-Up Nanofablication, Development of Molecular Machinery as Nonviral Vectors

    Tomomi Jinta, Takeshi Nagasaki (Part: Contributor )

    American Scientific Publishers  2009

  • Non-viral Gene Therapy: Gene Design and Derivery, 2.4 Active Transport of Exogenous Genes into the Nucleus

    (Part: Joint Work )

    Springer-Verlag, Tokyo  2005

  • Non-viral Gene Therapy: Gene Design and Derivery, 2.2 Active DNA Release from Complexes

    (Part: Single Work )

    Springer-Verlag, Tokyo  2005

Review Papers (Misc) 【 display / non-display

  • Photoresponsive Gene Delivery System: Photoregulation of Intracellular Trafficking Using Photoresponsive Liposome

    Takeshi Nagasaki, Tsutomu Hamada

    Laser Society of Japan  45 ( 11 ) 696 - 700 2017.11  [Refereed]  [Invited]

     View Summary

    Since light as a stimulus can be controlled both temporally and spatially, photo-irradiation improves both the endosomal escape of exogenous DNA and DNA release from the complexes with carriers. When a photo-responsive cationic lipid formed a cell-sized giant vesicle, we observed the photo-isomerization effect of azobenzene on its shape change. Photoswitching the membrane line tension induced reversible transitions between a closed sphere and an opened disk with a bilayer pore. In a transfection experiment using a photoresponsive cationic lipid, UV irradiation improved the transfection efficiency. After the lipoplexes passed through the plasma membrane by endocytosis, trans to cis isomerization of azobenzene moiety destabilized the vesicle membrane, thus accelerating not only the membrane fusion of the photo-responsive lipid vesicles but also the endosomal escape of the exogenous DNA.

  • Preparation and Characterization of a Novel Bispecific Antibody That Targets Her2 and BSH for Boron Neutron Capture Therapy

    Taisei Kanai, Taro Tachibana, Takeshi Nakanishi, Takeshi Nagasaki, Mitsunori Kirihata, Yoshihide Hattori, Yu Sanada, Yoshinori Sakurai and Shin-ichiro Masunaga

    KURNS Progress Report 2019  2020.04

  • 光に応答する遺伝子デリバリーシステム 〜エンドソーム脱出を中心とした細胞内トラフィッキング光制御〜

    長崎 健, 濱田 勉

    レーザー研究  45 ( 11 ) 696 - 700 2017.11  [Refereed]  [Invited]

     View Summary

    アゾベンゼンを基体とする光応答性脂質はtrans- cisの構造変化によりその分子集合体の形態が大きく変化することが明らかとなった.この変化は光異性化による膜の物性変化に基づく.またこの変化により他の二分子膜との融合などが誘起され,エンドサイトーシスにより細胞内に取り込まれた場合にはエンドソーム膜との融合により,薬物の細胞内輸送にも大きな影響を与えることが明らかとなった.実際,光開裂性脂質を用いた時,蛍光ラベル化複合体の蛍光顕微鏡観察によりエンドソーム脱出の光促進が確認出来た.

  • 健康・医療用マテリアルとしてのβ-1,3-グルカン

    鈴木利雄, 長崎 健

    機能材料  30 ( 9 ) 54 - 62 2010  [Refereed]  [Invited]

  • The Concept of Molecular Machinery Is Useful for Design of Stimuli-Responsive Gene Delivery Systems in the Mammalian Cell.

    J. Incl. Phenom. Macrocycl. Chem.  58 ( 3-4 ) 205 - 219 2007

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Conference Activities & Talks 【 display / non-display

  • Development of self-healing concrete containing bacteria immobilized on multilayer alginate beads

    2022.01 

  • Functional evaluation of bispecific antibody against BSH and EGFR

    Kohei Yoshikawa, Taro Tachibana, Takeshi Nakanishi, Takeshi Nagasaki

    2022.01 

  • Preparation of lactose-presented cyclodextrin vesicles for asialoglycoprotein receptor targeting

    Nao Tateishi, Hideki Azuma, Takeshi Nagasaki

    2022.01 

  • A novel injectable biomaterial enabling gelation upon contact with soft tissue surface

    Sunao Matsui, Takeshi Nagasaki Tetsuji Yamaoka

    2022.01 

  • Basic evaluation of a cross-linked gelatin hemostat

    Hironori Arima, Kido Hirotsugu,Takeshi Nagasaki, Kenji Ohata, Takeo Goto

    日米バイオマテリアル学会・ジョイントシンポジウム2021  2022.01 

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Grant-in-Aid for Scientific Research 【 display / non-display

  • Development of Inorganic Boron Cluster-fused Delivery Materials for the Neutron Capture Therapy

     Representative

    Project Year :

    2011.04
    -
    2013.03
     

  • Development of multifunctional vectors

    Grant-in-Aid for Scientific Research(C) Representative

    Project Year :

    2005.04
    -
    2007.03
     

  • Study on interaction between the photoresponsive dendrimer and biorelative compounds

    Grant-in-Aid for Scientific Research(C) Representative

    Project Year :

    1997.04
    -
    2000.03
     

 

Other educational activity and Special note 【 display / non-display

  • Contribution to University-wide Cross-training program

    (2021)

  • Office hours

    (2021)

  • Contribution to FD activities

    (2021)

  • Contribution to University-wide Cross-training program

    (2020)

  • Office hours

    (2020)

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Educational activity record 【 display / non-display

  • Academic year : 2021

     View Details

    Number of instructed the graduation thesis
    1
    Number of graduation thesis reviews
    4
    Number of instructed the Master course
    8
    Number of instructed the Doctoral course
    1
    Number of master's thesis reviews (chief)
    4
    Number of master's thesis reviews (vice-chief)
    4
    Number of doctoral thesis reviews (chief)
    0
    Number of doctoral thesis reviews (vice-chief)
    0
  • Academic year : 2020

     View Details

    Number of instructed the graduation thesis
    3
    Number of graduation thesis reviews
    6
    Number of instructed the Master course
    4
    Number of instructed the Doctoral course
    1
    Number of master's thesis reviews (chief)
    0
    Number of master's thesis reviews (vice-chief)
    4
    Number of doctoral thesis reviews (chief)
    0
    Number of doctoral thesis reviews (vice-chief)
    0
  • Academic year : 2010

     View Details

    Number of instructed the graduation thesis
    3
    Number of graduation thesis reviews
    3
    Number of instructed the Master course
    5
    Number of instructed the Doctoral course
    2
    Number of master's thesis reviews (chief)
    5
    Number of master's thesis reviews (vice-chief)
    4
    Number of doctoral thesis reviews (chief)
    0
    Number of doctoral thesis reviews (vice-chief)
    0
 

Theme of Possible Research Exchange 【 display / non-display

  • Development of cell culture devise

    Request for collaborative research : The private sector, such as other institutions

    Type of research exchange : Technical consultation, Consignment study, Collaborative research, Lecture

    Keyword : cell culture, polycation, cell adhesion

  • Development of biopolymer-based gene carrier

    Request for collaborative research : The private sector, such as other institutions

    Type of research exchange : Technical consultation, Consignment study, Collaborative research, Lecture

    Keyword : transfection, biopolymer, biodegradability, polycation, liposome

  • Controlled drug delivery by using functional protein

    Request for collaborative research : The private sector, such as other institutions

    Type of research exchange : Technical consultation, Consignment study, Collaborative research, Lecture

    Keyword : drug delivery, intracellular trafficking

 

Foreigner acceptance 【 display / non-display

  • Academic year : 2017

     View Details

    Number of International Students
    1
  • Academic year : 2010

     View Details

    Number of foreigners accepted
    1
    Number of International Students
    2