KOYANAGI Mitsumasa

写真a

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Title

Associate Professor

Laboratory location

Sugimoto Campus

Mail Address

E-mail address

Degree 【 display / non-display

  • Kyoto University -  D.sci

Research Areas 【 display / non-display

Photobiology, Molecular Evolution

Research Interests 【 display / non-display

GPCR, Photoreception, Photoreceptor, Light sensing, Photobiology, Optogenetics, Receptor, Sensory system, Color vision, Vision

Research Career 【 display / non-display

  • Origin and diversity of the animal photoreception.

    (Individual) Project Year :

    2005.04
     
     

    Keyword in research subject:  photoreception, rhodopsin

  • Functional analyses of non-image-forming color vision.

    (Individual) Project Year :

    2006.04
     
     

    Keyword in research subject:  non-visual, rhodopsin, color vision

Association Memberships 【 display / non-display

  • THE ZOOLOGICAL SOCIETY OF JAPAN

Awards & Honors 【 display / non-display

  • JSPS Award

    2017  

  • Promotion Award of the Zoological Society of Japan

    2013  

    Winner : KOYANAGI Mitsumasa

  • Nature Industry Award of Osaka Science and Technology Center

    2012  

  • Promotion Award of the Photobiology Association of Japan

    2012  

  • Yoshida Prize for Young Researchers of the Japanese Society for Comparative Physiology and Biochemistry

    2006  

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Science   Biology and Geosciences Course   Associate Professor  

  • Osaka City University   The OCU Advanced Research Institute for Natural Science and Technology (OCARINA)   Researcher  

Career 【 display / non-display

  • 2015.04
    -
    Today

    Osaka City University   OCARINA   Researcher (Concurrent)

  • 2013.10
    -
    2017.03

    JST   PRESTO Researcher (Concurrent)

  • 2010.10
    -
    Today

    Osaka City University   Graduate School of Science   Associate Professor

  • 2006.04
    -
    2010.09

    Osaka City University   Graduate School of Science   Lecturer

  • 2004.04
    -
    2006.03

    Osaka University   Graduate School of Science   Assistant Professor

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Graduate School 【 display / non-display

  • 1997.04
    -
    2001.03

    Kyoto University  Graduate School, Division of Natural Science 

  • 1995.04
    -
    1997.03

    Kyoto University  Graduate School, Division of Natural Science 

Graduating School 【 display / non-display

  • 1991.04
    -
    1995.03

    Kyoto University   Faculty of Science  

 

Published Papers 【 display / non-display

  • Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates

    Hara Yuichiro, Yamaguchi Kazuaki, Onimaru Koh, Kadota Mitsutaka, Koyanagi Mitsumasa, Keeley Sean D., Tatsumi Kaori, Tanaka Kaori, Motone Fumio, Kageyama Yuka, Nozu Ryo, Adachi Noritaka, Nishimura Osamu, Nakagawa Reiko, Tanegashima Chiharu, Kiyatake Itsuki, Matsumoto Rui, Murakumo Kiyomi, Nishida Kiyonori, Terakita Akihisa, Kuratani Shigeru, Sato Keiichi, Hyodo Susumu, Kuraku Shigehiro

    NATURE ECOLOGY & EVOLUTION  2 ( 11 ) 1761 - 1771 2018.11  [Refereed]

    DOI

  • Color opponency with a single kind of bistable opsin in the zebrafish pineal organ

    Wada Seiji, Shen Baoguo, Kawano-Yamashita Emi, Nagata Takashi, Hibi Masahiko, Tamotsu Satoshi, Koyanagi Mitsumasa, Terakita Akihisa

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  115 ( 44 ) 11310 - 11315 2018.10  [Refereed]

    DOI

  • Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish

    Gerrard Elliot, Mutt Eshita, Nagata Takashi, Koyanagi Mitsumasa, Flock Tilman, Lesca Elena, Schertler Gebhard F. X., Terakita Akihisa, Deupi Xavier, Lucas Robert J.

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  115 ( 24 ) 6201 - 6206 2018.06  [Refereed]

    DOI

  • An all-trans-retinal-binding opsin peropsin as a potential dark-active and light-inactivated G protein-coupled receptor

    Nagata Takashi, Koyanagi Mitsumasa, Lucas Robert, Terakita Akihisa

    SCIENTIFIC REPORTS  8 2018.02  [Refereed]

    DOI

  • Expression and light-dependent translocation of beta-arrestin in the visual system of the terrestrial slug Limax valentianus

    Matsuo Ryota, Takatori Yuka, Hamada Shun, Koyanagi Mitsumasa, Matsuo Yuko

    JOURNAL OF EXPERIMENTAL BIOLOGY  220 ( 18 ) 3301 - 3314 2017.09  [Refereed]

    DOI

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Books etc 【 display / non-display

  • Optogenetics : light-sensing proteins and their applications

    八尾 寛, 神取 秀樹, 小泉 周 (Part: Joint Work )

    Springer  2015

  • Evolution of visual and non-visual pigments

    Hunt David M. (Part: Joint Work )

    Springer  2014

  • 昆虫とクモの仲間

    針山 孝彦, 小柳 光正, 嬉 正勝, 妹尾 圭司, 小泉 修, 日本比較生理生化学会 (Part: Single Work )

    共立出版  2012

    CiNii

  • ゾウリムシ,ヒドラ,貝,エビなど

    針山 孝彦, 小柳 光正, 嬉 正勝, 妹尾 圭司, 小泉 修, 日本比較生理生化学会 (Part: Single Work )

    共立出版  2012

    CiNii

  • ウニ,ナマコから脊椎動物へ

    針山 孝彦, 小柳 光正, 嬉 正勝, 妹尾 圭司, 小泉 修, 日本比較生理生化学会 (Part: Single Work )

    共立出版  2012

    CiNii

Review Papers (Misc) 【 display / non-display

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Conference Activities & Talks 【 display / non-display

  • Detection of “color changes” with a single kind of opsin in the zebrafish pineal organ

    Seiji Wada, Baoguo Shen, Emi Kawano-Yamashita, Takashi Nagata, Masahiro Hibi, Satoshi Tamotsu, Mitsumasa Koyanagi, Akihisa Terakita

    10th OCARINA International Symposium  2019.03 

  • A nobel type of opsin with optogenetic potential: animal opsin-based photopigment as a potential dark-active and light-Inactivated G protein-coupled receptor

    Takashi Nagata, Mitsumasa Koyanagi, Robert Lucas, Akihisa Terakita

    10th OCARINA International Symposium  2019.03 

  • Evaluation of the pineal wavelength discrimination based on a pineal-specific opsin parapinopsin in the zebrafish behaviours

    Tomoka Saito, Seiji wada, Baoguo Shen, Takashi Nagata, Mitsumasa Koyanagi and Akihisa Terakita

    10th OCARINA International Symposium  2019.03 

  • Behavioral investigation of non-visual photoreception with pineal-specific opsin- knockout zebrafish

    Genki Nakata, Seiji Wada, Mitsumasa Koyanagi and Akihisa Terakita

    10th OCARINA International Symposium  2019.03 

  • Animal opsins: non-visual functions and optogenetic applications

    Akihisa Terakita, Mitsumasa Koyanagi

    10th OCARINA International Symposium  2019.03 

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Grant-in-Aid for Scientific Research 【 display / non-display

  • Study on a non-visual photoreception lost in the course of mammalian evolution

    Project/Area Number : 15K14568  Grant-in-Aid for challenging Exploratory Research Representative

    Project Year :

    2015.04
    -
    2017.03
     

    Partaker : TERAKITA Akihisa

     View Summary

    We discovered a photoreceptor gene (opsin), which does not exist in eutherian genomes, in marsupial genomes. In this study, we carried out functional analyses of the marsupial opsin spectroscopically and biochemically to understand the diversity of photoreception in mammals. We found that the marsupial opsin indeed forms a photosensitive pigment. In addition, histochemical analysis revealed that the marsupial opsin exhibits a different expression pattern from other opsins in opossum, suggesting a novel photoreception in mammals.

  • Investigation of the diversity of visual and non-visual UV reception in jumping spiders

    Project/Area Number : 26291070  Grant-in-Aid for Scientific Research(B) Representative

    Project Year :

    2014.04
    -
    2018.03
     

  • Functional analysis of genetic variation in melanoposin, a non-visual photoreceptor protein for circadian photoentrainment and its implication for phenotype

    Project/Area Number : 23657175  Grant-in-Aid for challenging Exploratory Research Representative

    Project Year :

    2011
    -
    2012
     

     View Summary

    We succeeded in a large scale expression of a mammalian melanopsin, a circadian photoreceptor protein, and its polymorphic variant in cultured cells, and elucidated photochemical and biochemical characteristics of them. We also

  • Investigation of the pineal wavelength discrimination in lower vertebrates

    Project/Area Number : 22687005  Grant-in-Aid for Young Scientists(A) Representative

    Project Year :

    2010.04
    -
    2014.03
     

     View Summary

    In lower vertebrates, pineal and related organs detect the ratio of UV to visible lights, suggesting that wavelengths of environmental light are discriminated by these organs independently of eyes. Recently, we found that parapinopsin is a UV sensitive photopigment that underlies the UV reception for wavelength discrimination in the lamprey pineal. Here, we carried out the parapinopsin-based investigation of the pineal wavelength discrimination in varied lower vertebrates and revealed the diversity and generality of the wavelength discrimination mechanism. Furthermore, by using transgenic technique, we obtained a clue to the physiological roles of the pineal wavelength discrimination. We also found that a homologue of another non-visual photopigment Opn3 has an unique characteristic for functioning as a light sensor in extraocular tissues.

  • Functional analyses of rhodops in-related non-visual photopigments at molecular and neural levels.

    Project/Area Number : 20770057  Grant-in-Aid for Young Scientists(B) Representative

    Project Year :

    2008
    -
    2009
     

     View Summary

    Many animals sense light signals for visual and non-visual functions. On the contrary to the vision, which has been well investigated, the neural mechanism and physiological role of non-visual photoreception are largely unknown. In this study, we focused on some non-visual photopigments and investigated the molecular and neural mechanism of the non-visual photoreceptions by using mammalian cell expression system and transgenic technique. As results, we succeeded to establish several transgenic zebrafish lines for future studies on non-visual photoreception.

 

Other educational activity and Special note 【 display / non-display

  • Contribution to FD activities

    (2018)

  • Contribution to FD activities

    (2017)

 

Foreigner acceptance 【 display / non-display

  • Academic year : 2018

     View Details

    Number of foreigners accepted
    1
    Number of International Students
    1

    United Kingdom

  • Academic year : 2017

     View Details

    Number of foreigners accepted
    1
    Number of International Students
    1

    Germany