HINO Masayuki

写真a

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Title

Professor

Laboratory location

Abeno Campus

Mail Address

E-mail address

Degree 【 display / non-display

  • The University of Tokyo -  Doctor of Medicine

Research Areas 【 display / non-display

Hematology, Laboratory medicine

Research subject summary 【 display / non-display

  • hematopoietic stem cell transplantation, leukemia, lymphoma

Research Career 【 display / non-display

  • Hematopoietic stem cell transplantation

    (Collaboration in Organization) Project Year :

    1992.04
    -
    Today

    Keyword in research subject:  stem cell, transplantation

  • reproduction medicine

    (Collaboration in Organization) Project Year :

    1992.04
    -
    Today

    Keyword in research subject:  mesenchymal stem cell

  • Amplification and differentiation of isolated hematopoietic stem cell

    (Individual) Project Year :

    1991.04
    -
    Today

    Keyword in research subject:  hematopoietic stem cell

  • Therapy

    (Collaboration in Japan) Project Year :

    1991.04
    -
    Today

  • Mechanism of leukemic cell differentiation

    (Individual) Project Year :

    1987.04
    -
    Today

    Keyword in research subject:  leukemia, differentiation

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Association Memberships 【 display / non-display

  • Japanese Society of Laboratory Hematology

  • American Society of Hematology

Committee Memberships 【 display / non-display

  • 2000
    -
    Today

    Japanese Society of Laboratory Hematology  

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Medicine   Clinical Medicine Course   Professor  

Career 【 display / non-display

  • 2002
    -
    Today

    Osaka City Universit, Graduate School of Medicine   Hematology  

  • 2002.04
    -
    Today

    Osaka City University Hospital  

Graduating School 【 display / non-display

  • 1979.04
    -
    1985.03

    Osaka City University   Faculty of Medicine  

 

Published Papers 【 display / non-display

  • Recurrence of Acute Lymphoblastic Leukemia with Bone Marrow Necrosis: A Case Report and Review of the Literature on the MRI Features of Bone Marrow Necrosis.

    Harada N, Nishimoto M, Ikemoto A, Okamura H, Koh S, Nanno S, Nakashima Y, Koh H, Nakane T, Kuwae Y, Ohsawa M, Hino M, Nakamae H

    一般社団法人 日本内科学会 Internal medicine (Tokyo, Japan)  60 ( 7 ) 1083 - 1088 2021.04  [Refereed]

     View Summary

    <p>Bone marrow necrosis (BMN) is a rare but important complication of hematological malignancies. We report the case of a 52-year-old male patient with a recurrence of acute lymphoblastic leukemia (ALL) accompanied by BMN. After re-induction therapy, bone marrow aspiration (BMA) and biopsy from the iliac bone showed necrotic cells and eosinophilic debris, respectively. Magnetic resonance imaging (MRI) showed heterogeneous signals in the bilateral iliac bone, possibly reflecting various stages of BMN. BMA from the sternum eventually revealed the recurrence of ALL after a few weeks. Comprehensive assessments, including MRI and repeated bone marrow tests, are required when evaluating the underlying hematological malignancies of patients with BMN. </p>

    DOI PubMed CiNii

  • Outcomes of ixazomib/lenalidomide/dexamethasone for multiple myeloma: A multicenter retrospective analysis

    Takakuwa Teruhito, Yamamura Ryosuke, Ohta Kensuke, Kaneko Hitomi, Imada Kazunori, Nakaya Aya, Fuchida Shin-ichi, Shibayama Hirohiko, Matsuda Mitsuhiro, Shimazu Yutaka, Adachi Yoko, Kosugi Satoru, Uchiyama Hitoji, Tanaka Hirokazu, Hanamoto Hitoshi, Shimura Yuji, Kanda Junya, Onda Yoshiyuki, Uoshima Nobuhiko, Yagi Hideo, Yoshihara Satoshi, Hino Masayuki, Shimazaki Chihiro, Takaori-Kondo Akifumi, Kuroda Junya, Matsumura Itaru, Kanakura Yuzuru, Nomura Shosaku

    EUROPEAN JOURNAL OF HAEMATOLOGY  106 ( 4 ) 555 - 562 2021.04  [Refereed]

    DOI PubMed

  • Plateau is a prognostic factor of lenalidomide therapy for previously treated multiple myeloma.

    Takakuwa T, Ohta K, Nakatani E, Ito T, Kaneko H, Fuchida SI, Shimura Y, Yagi H, Shibayama H, Kanda J, Uchiyama H, Kosugi S, Tanaka H, Kawata E, Uoshima N, Ishikawa J, Shibano M, Karasuno T, Shindo M, Shimizu Y, Imada K, Kanakura Y, Kuroda J, Hino M, Nomura S, Takaori-Kondo A, Shimazaki C, Matsumura I

    Hematological oncology  2021.03  [Refereed]

    DOI PubMed

  • High-grade B-cell lymphoma developed during the treatment of chronic myeloid leukemia with bosutinib

    Takakuwa Teruhito, Sakai Ryota, Koh Shiro, Okamura Hiroshi, Nanno Satoru, Nakashima Yasuhiro, Nakane Takahiko, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    CLINICAL CASE REPORTS  9 ( 3 ) 1344 - 1349 2021.03  [Refereed]

    DOI PubMed

  • Pretransplant plasma brain natriuretic peptide and N-terminal probrain natriuretic peptide are more useful prognostic markers of overall survival after allogeneic hematopoietic cell transplantation than echocardiography

    Harada Naonori, Okamura Hiroshi, Nakane Takahiko, Koh Shiro, Nanno Satoru, Nishimoto Mitsutaka, Hirose Asao, Nakamae Mika, Nakashima Yasuhiro, Koh Hideo, Hino Masayuki, Nakamae Hirohisa

    BONE MARROW TRANSPLANTATION  2021.02  [Refereed]

    DOI PubMed

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Books etc 【 display / non-display

  • 造血幹細胞移植時の心筋障害

    中前博久, 中根孝彦, 日野雅之 (Part: Single Work )

    医薬ジャーナル社、血液疾患治療に伴う合併症対策  2015.08

Review Papers (Misc) 【 display / non-display

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Conference Activities & Talks 【 display / non-display

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Grant-in-Aid for Scientific Research 【 display / non-display

  • Establishment of prognosis prediction model after hematopoietic stem cell transplantation based on pretransplantation data

    Project/Area Number : 20K07788  Grant-in-Aid for Scientific Research(C) Representative

    Project Year :

    2020.04
    -
    2024.03
     

  • Establishment of early and simple diagnostic method for complications and recurrence after hematopoietic stem cell transplantation

    Project/Area Number : 17K09017  Grant-in-Aid for Scientific Research(C) Representative

    Project Year :

    2017.04
    -
    2020.03
     

     View Summary

    The pretransplant WT1 mRNA level was a powerful prognostic factor in allo-HCT for non-CR AML patients. High peak serum IL-6 level after HLA-haploidentical allogeneic hematopoietic cell transplantation with post-transplantation cyclophosphamide (PT/Cy-haplo) was identified a significant risk factor for very severe cytokine release syndrome (CRS) and poor 3-year overall survival. Counts of CD4+ T-cell subsets, CD8+ T-cell subsets, and NK cells were lower in PT/Cy-haplo than those in HLA-matched related HCT. The immune recovery pace in PT/Cy-haplo subsequently caught up with that of the other grafts. The regulatory T cells (Tregs) to conventional CD4+ T-cell (Tcon) ratio was significantly higher in PT/Cy-haplo. A higher Tregs-to-Tcon ratio was significantly associated with a lower incidence of chronic GVHD. A diagnostic approach using per-rectal portal scintigraphy for sinusoidal obstruction syndrome was useful.

  • Spinal cord regeneration by intercostal nerve transfer for spinal cord injury

    Project/Area Number : 16K10827  Grant-in-Aid for Scientific Research(C) Representative

    Project Year :

    2016.04
    -
    2019.03
     

     View Summary

    A cure for spinal cord injury has not yet been established. In this study, using the rat thoracic spinal cord injury model, the stump of the intercostal nerve on the cranial side of the injury site was transferred into the spinal cord caudal to the injury site across the injury site. At 8 weeks after surgery, the hindlimb motor function of transferred rat was significantly improved than that of control animals. Progression of the transcostal nerve stump into the spinal cord of the axon was not confirmed by technical causes, but has been reported to progress in past papers. As compared to the mRNA expressed in the somata of the transferred intercostal nerve, which was transferred and then cut (control), pathway analysis revealed that many contained axonal inducer mRNAs.

  • Hematopoietic Stem Cell Transplantation

    Project/Area Number : 23591423  Grant-in-Aid for Scientific Research(C) Representative

    Project Year :

    2011
    -
    2013
     

    Partaker : NAKAMAE Hirohisa

     View Summary

    A myeloablative regimen involved high-dose TBI impaired cardiac function. A high s-ferritin level before HCT might be associated with the development of LVH in the chronic phase of HCT. A high s-ferritin level after HCT might be a prognostic factor. Eosinophilia after allo-HCT was associated with better OS and a lower relapse rate. Dysregulated balance between Th1 and Th2 cytokines might play an important role in the incidence of HPS after allo-HCT. Prospective pilot study of HLA haplo-identical allogeneic PBSCT using cyclophosphamide post-transplantation for patients with a poor-prognosis or refractory leukemia and MDS showed that except for one patient who died due to disease progression, full donor T-cell chimerism was achieved at day 30 in all patients, 53% of patients developed grade II-III acute GVHD, the cumulative incidence of TRM at one year was 13%, and the OS at one year of all patients, patients in remission and those with active disease were 43%, 75% and 31%, respectively.

  • Evaluation and treatment for complications of hematopoietic stem cell transplantation

    Project/Area Number : 19591128  Grant-in-Aid for Scientific Research(C) Representative

    Project Year :

    2007
    -
    2009
     

    Partaker : NAKAMAE Hirohisa, KOH Ki-Ryang

     View Summary

    In this study, clinical trial of angiotensin II receptor blocker, Valsartan, to prevent chronic cardiotoxic damage following standard chemotherapy with cyclophosphamide, doxorubicin, vincristine, prednisolong±rituximab was performed. This study shows that (1)reduced-intensity allogeneic stem cell transplantation (RIST) is well-tolerated in patients with cardiac dysfunction ; (2)monitoring HRV may be useful in predicting stem cell transplantation is a useful, noninvasive predictor for the development of bronchiolitis obliterans syndrome (BOS) and idiopathic pneumonia syndrome (IPS) ; (4)heart rate variability analysis is useful in evaluating and predicting the adverse effects of cardiovascular complications in peripheral blood stem cell harvest.

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Other educational activity and Special note 【 display / non-display

  • Class teacher

    (2020)

  • Class teacher

    (2019)

  • Contribution to FD activities

    (2019)

  • Contribution to FD activities

    (2017)

 

Foreigner acceptance 【 display / non-display

  • Academic year : 2019

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    Number of International Students
    1

    タイ

  • Academic year : 2018

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    Number of International Students
    1

    インドネシア

  • Academic year : 2016

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    Number of International Students
    2

    オーストラリア、韓国

  • Academic year : 2015

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    Number of International Students
    2

    台湾、インドネシア