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Associate Professor

Laboratory location

Sugimoto Campus

Degree 【 display / non-display

  •  -  Doctor of Science

Research Areas 【 display / non-display

Molecular biology, Medical Organism Engineering and Material Science of Organism

Research Career 【 display / non-display

  • Controlling cell growth and differentiation on patterned scaffolds


    Keyword in research subject:  growth factor, cell differentiation, patterned scaffold

  • high efficient siRNA/miRNA sturctures


    Keyword in research subject:  RNAi, siRNA, miRNA

  • in vitro selection of aptamer for new targets


    Keyword in research subject:  aptamer, nucleic acids, in vitro selection

  • Functional Development of Keratin Protein

    (Collaboration in Organization)

    Keyword in research subject:  Keratin

Association Memberships 【 display / non-display

  • The Society for Biotechnology, Japan


Committee Memberships 【 display / non-display

  • 2007.06

    The Society for Biotechnology, Japan  

Current Career 【 display / non-display

  • Osaka City University   Graduate School of Engineering   Applied Chemistry and Bioengineering Course   Associate Professor  

Graduate School 【 display / non-display


    Osaka City University  Graduate School, Division of Natural Science 

Graduating School 【 display / non-display


    Osaka City University   Faculty of Science  


Published Papers 【 display / non-display

  • LidNA, a novel miRNA inhibitor constructed with unmodified DNA

    Akira Tachibana, Yui Yamada, Hiroyuki Ida, Satoshi Saito, Toshizumi Tanabe

    ELSEVIER  586   1529 - 1532 2012.05

  • SmaI cloning with the regeneration of SmaI site for sequential PCR product cloning

    361   143 - 145 2007

  • Acquisition of cell-adhesion capability of the surface of crosslinked albumin films irradiated with atmospheric-pressure plasma jets

    Shirafuji Tatsuru, Iwamura Mami, Taga Ryosuke, Kashiwagi Yukiyasu, Nakajima Kota, Ogata Yuji, Tanaka Kenji, Tachibana Akira, Tanabe Toshizumi

    Institute of Physics JAPANESE JOURNAL OF APPLIED PHYSICS  55 ( 7 )  2016.07  [Refereed]

     View Summary

    Crosslinked albumin films, to which L929 cells do not attach by nature, acquire the L929-cell-adhesion capability by irradiation of an atmospheric-pressure plasma jet (APPJ) of He gas. The number of attached cells was 2.6 × 10<sup>4</sup>cells/cm<sup>2</sup>after the APPJ irradiation for 180 s, while conventional UV photolithography, which was performed in our previous work, required 2 h to obtain the same order of magnitude of the number of attached cells. The contact angle of samples decreased steeply from 105 to 38° in the first 10 s irradiation, but decreased quite gradually from 38 to 32° with increasing irradiation time from 10 to 180 s. In contrast to the nonlinear variation in the contact angles, the number of attached cells almost linearly increased from 4.5 × 10<sup>3</sup>to 2.6 × 10<sup>4</sup>cells/cm<sup>2</sup>with increasing treatment time. X-ray photoelectron spectroscopy of the samples indicated that hydrophilic functional groups of C–C=O gradually formed with increasing APPJ irradiation time up to 180 s. These results suggest that the cell-adhesion capability of the crosslinked albumin films is not simply explained by the decrease in contact angle but also by the formation of oxidized functional groups on the surface. The effects of UV and vacuum UV light from APPJ were negligible, which indicates that the formation of oxidized functional groups on the surface is not caused by photon-assisted surface reactions but by reactions involving chemically active species supplied from APPJ.

    DOI CiNii

  • Changes in Cell Adhesiveness and Physicochemical Properties of Cross-Linked Albumin Films after Ultraviolet Irradiation

    Yamazoe Hironori, Nakanishi Hisashi, Kashiwagi Yukiyasu, Nakamoto Masami, Tachibana Akira, Hagihara Yoshihisa, Tanabe Toshizumi

    LANGMUIR  32 ( 1 ) 203 - 210 2016.01  [Refereed]


  • Preparation of keratin and chemically modified keratin hydrogels and their evaluation as cell substrate with drug releasing ability

    Nakata Ryo, Osumi Yu, Miyagawa Shoko, Tachibana Akira, Tanabe Toshizumi

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING  120 ( 1 ) 111 - 116 2015.07  [Refereed]


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Review Papers (Misc) 【 display / non-display

  • Keratins: prospective proteinous biomaterial

    Recent Res. Develop. Protein Eng.  00   00 - 00 2001

Conference Activities & Talks 【 display / non-display

  • Long-miRNA* strands enhance the activity of microRNA



Theme of Possible Research Exchange 【 display / non-display

  • Cell cultivation with protein biomaterials

    Keyword : Biomaterials, Cell cultivation